摘要背景 器质性和遗传性恶性室性心律失常因可导致猝死而严重危害人民生命健康,目前国内恶性室性心律失常发病率和危险因素不清、治疗方式有待完善.基本原理 明确我国器质性和遗传性恶性室性心律失常的发病率、危险分层及危险因素研究,有助于指导早期干预、预防心脏性猝死;导管消融、药物治疗和自主神经干预方法的完善将为器质性和遗传性恶性室性心律失常提供低价高效的诊疗策略.设计方案 项目设置4个课题:①国人恶性室性心律失常危险分层预后评估研究;②恶性室性心律失常的自主神经功能评估及干预策略研究;③器质性室性心律失常基质干预策略研究;④遗传性恶性室性心律失常分布、危险评估与干预研究.各课题相互关联、互为支持,形成有机的结合.结论 本研究将建立国人器质性和遗传性室性心律失常数据库及多维度危险评估体系;探索适合国情的低价高效、创新性的多个治疗策略;确立国人恶性室性心律失常危险分层并指导早期干预治疗决策.

abstractsBackground Malignant organic and hereditary ventricular arrhythmias lead to sudden death,accounting for a major death cause of Chinese individuals. Currently,the incidence and risk factors of ventricular arrhythmia remain unclear,and the therapeutics of malignant ventricular arrhythmia require further revising. Rationale The study of the incidence and risk factors of ventricular tachycardia with organic or heritable heart diseases in China will promote early intervention against sudden cardiac death. The improvement of catheter ablation,drug therapies and autonomic nerve intervention will provide patients with lower cost and more efficient diagnosis and treatment strategy. Design The study consists of four parts.①Risk stratification of ventricular tachycardia with organic or heritable heart diseases in China.②Evaluation and intervention strategies of autonomic nervous in ventricular tachycardia of organic heart disease.③Substrate intervention strategy for ventricular arrhythmia.④Demographics,risk stratification and intervention of hereditary malignant ventricular arrhythmia. Conclusion The study will construct the databases for ventricular arrhythmia and multidimensional risk stratification system,predicting the risk of the malignant ventricular arrhythmia and the reciprocal effective interventions.