摘要目的 观察人类免疫缺陷病毒(HIV)感染对起搏阈值的影响.方法 收集首都医科大学附属北京地坛医院2010年3月至2017年10月HIV感染合并病态窦房结综合征(SSS)住院患者5例为研究对象,无HIV感染的SSS 10例作为对照,均行双腔心脏起搏器植入术,均采用心房被动、心室主动固定导线.观察两组患者起搏器植入术术中、术后1周、1、3、6、12个月时心房、心室导线的起搏阈值.结果 两组植入时阻抗、阈值、P/R波振幅差异无统计学意义(P＞0.05),术后1周进行阈值测试,两组患者阈值均较植入时下降,但两组间阈值差异无统计学意义(P＞0.05).术后1个月阈值较术后1周轻度升高,3个月后有所下降,至术后6～12个月稳定,两组阈值在随访期内差异均无统计学意义(P＞0.05).结论 HIV感染患者植入永久心脏起搏器是安全、可靠、可行的.

abstractsObjective To observe the influenceofhuman immunodeficiencyvirus (HIV) infection onpacing threshold.Methods Five patients with HIV and sick sinus syndrome were studied,10 cases of sick sinussyndrome without H IV infection as control group.All patients underwent dual chamber pacemaker implantation.Atrialpassive and ventricular active fixed pacing leads were used.The pacing thresholds of atrial and ventricular leads wereobserved during operation and after pacemaker implantation at 1 week,1 month,3 months,6 months and 12 months.Results There was no significant difference in impedance,threshold,and P/R wave amplitude between the twogroupsatimplantation (P＞0.05).Threshold test was performed 1 week after the implantation.Threshold values of two groups were lower than those at implantation,but there was no significant difference between the two groups (P＞0.05).Threshold increased slightly in 1 month after implantation,decreased slightly in 3 months,and remained stable in 6-12months after implantation.There was no significant difference between the two groups during the follow-up period (P＞0.05).Conclusion Implantation of permanent cardiac pacemaker in HIVinfected patients is safe,reliable and feasible.