摘要目的:初步比较经导管主动脉瓣置换术（TAVR）治疗二叶式主动脉瓣（BAV）与三叶式主动脉瓣（TAV）狭窄的中期预后。方法:本研究为回顾性研究。选取2016年4月至2018年8月在广东省人民医院行TAVR治疗且随访时间超过1年的症状性重度主动脉瓣狭窄患者。依据主动脉CT血管成像结果将纳入患者分为BAV组和TAV组。主要终点为1年全因死亡和卒中组成的复合事件，次要终点为1年TAVR相关并发症。比较两组患者术后各终点事件发生率及超声心动图测得的血流动力学指标。并采用Kaplan-Meier生存分析比较两组间主要终点事件的发生情况。结果:本研究共入选49例重度主动脉瓣狭窄患者，年龄（73.6±6.3）岁，男性25例（51.0%）。其中BAV组32例，TAV组17例，随访时间为466（390，664）d。BAV组与TAV组患者的1年期全因死亡和卒中组成的复合事件发生率差异无统计学意义［6.3%（2/32）比5.9%（1/17）， P=1.00］；Kaplan-Meier曲线亦显示该复合事件在两组的发生风险差异无统计学意义（ HR=1.03，95% CI 0.09~11.24，Log-rank P=0.98）。两组的1年期全因死亡、卒中、心肌梗死、严重出血、主要血管并发症、新发心房颤动/心房扑动及永久起搏器置入的发生率差异均无统计学意义（ P均>0.05）；两组均未发生急性肾损伤（2级或3级）。两组术后1年血流动力学参数差异无统计学意义（ P均>0.05）。 结论:接受TAVR治疗的BAV与TAV狭窄患者的中期预后相似，但研究结论尚需大样本临床研究的长期随访进一步验证。

abstractsObjective:To compare the prognosis of transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) stenosis.Methods:This was a retrospective study. Patients with symptomatic severe aortic stenosis, who underwent TAVR with follow-up time more than one year in Guangdong Provincial People′s Hospital from April 2016 to August 2018, were included. According to aortic CT angiography, the patients were divided into BAV group and TAV group. The primary endpoint was the composite event of all-cause death and stroke, and the secondary endpoints were TAVR-related complications. Incidence of clinical endpoints and parameters derived from echocardiography were compared between the groups, and Kaplan-Meier survival analysis was used to compare the composite event between the two groups.Results:A total of 49 patients were included. The age was (73.6±6.3) years, and 25(51.0%) were male. There were 32 patients in BAV group and 17 in TAV group, the follow-up time was 466 (390, 664) days. The incidence of composite endpoint of death and stroke at one year were comparable in BAV and TAV groups (6.3% (2/32) vs. 5.9% (1/17), P=1.00). Kaplan-Meier curves also showed a similar risk of the composite endpoint( HR=1.03，95% CI 0.09-11.24，Log-rank P=0.98) between two groups. The incidence of all-cause death, stroke, myocardial infarction, severe bleeding, major vascular complications, new-onset atrial fibrillation or atrial flutter, and permanent pacemaker implantation were all similar between the two groups(all P>0.05), and there was no acute kidney injury (stage 2 or 3) in both groups. Echocardiographic parameters at one year were similar between the two groups (all P>0.05). Conclusions:The midterm prognosis of TAVR in patients with BAV and TAV stenosis is similar. Clinical trials of large sample size with long-term follow-up are warranted to verify our findings.