摘要目的 初步总结带Valsalva窦人工血管在保留主动脉瓣的主动脉根部替换术(David Ⅰ术)中的临床应用效果.方法 2008年1月至2011年5月,在David Ⅰ术式中应用带Valsalva窦人工血管治疗主动脉根部病变致主动脉瓣关闭不全(AI)15例.男14例,女1例；年龄33～67岁,平均(49.5±10.3)岁.术前心功能Ⅰ级11例,Ⅱ级4例；主动脉瓣反流中度9例,重度6例.同期手术包括主动脉弓置换9例,冠状动脉旁路移植(CABG)术4例,二尖瓣与三尖瓣成形1例,房间隔缺损(ASD)修补术1例.结果 围术期死亡2例,分别死于肺部感染和血源性感染性休克合并多脏器功能衰竭.全组平均体外循环(230.0±54.4) min,平均主动脉阻断(181.2±30.6) min.术后1周复查心功能均为Ⅰ级,主动脉瓣反流轻度6例,轻至中度1例,8例无反流.出院随访3～24个月,平均(8.8±5.9)个月.无主动脉瓣反流3例,轻度9例(3例6个月后复查转为无反流),中度1例(3个月后复查转为轻度).结论 David Ⅰ术式中应用带Valsalva窦人工血管治疗主动脉瓣叶及瓣环大致正常的主动脉根部病变是一种可选择的手术方案,早期手术效果良好,中、远期效果需进一步随访观察.

abstractsObjective To summarize the short-term therapeutic results of valve-sparing reimplantation procedure (David Ⅰ procedure) using Valsalva conduit in patients with aortic valve insufficiency due to aortic root disease.Methods From January 2008 to May 2011,David Ⅰ procedure was performed using Valsalva conduit in 15 patients with aortic insufficiency caused by aortic root disease,of which 14 males and 1 female,mean age was (49.5 ± 10.3) years old (from 33 to 67 years old).The evaluation of pre-operative heart functional and aortic valve regurgitation:11 in class Ⅰ,4 in class Ⅱ ; 9 with moderate and 6 with severe aortic insuffciency.Concomitant procedures included 4 CABG operations,9 aortic arch replacements,1 mitral annuloplasty and tricuspid annuloplasty,and 1 ASD repair operation.Results There was two intra-operative deaths occurred,one died of pulmonary infection,another one died of hemategenous septic shock and multiple organ failure.The mean extracorporeal circulation time was (230.0 ± 54.4) min,the aortic cross clamp time was (181.2 ± 30.6) min.One week after operation,the heart functional of all patients changed into class Ⅰ ; 8 patients had no aortic regurgitation,6 had gentle aortic regurgitation and 1 had moderate aortic regurgitation.After leaving hospital,13 patients were followed-up by (8.8 ± 5.9)months (ranged 3 to 24 months),3 were no and 9 with gentle (3 of which showed no aortic regurgitation in half past year)and 1 with moderate aortic regurgitation (this patient showed gentle aortic regurgitation in 3 months later).Conclusion David Ⅰ procedure using Valsalva conduit was a good option for patients with aortic valve insufficiency with approximate normal aortic leaflets and valvular ring,which could provide a good short-term operative effect.