摘要目的 与退行性二尖瓣关闭不全窦性心律的患者比较,评价迷宫Ⅲ手术治疗退行性二尖瓣关闭不全合并心房颤动的安全性和疗效.方法 2013年5月至2015年11月间我院行二尖瓣成形术的患者217例,其中窦性心律患者145例为对照组,房颤患者中同期行迷宫Ⅲ手术28例为试验组.以16项参数作为协变量,计算倾向性评分,找出最匹配的两组患者进行对比研究.比较两组手术的安全性和近中期疗效.结果 共28对匹配成功.两组均无住院死亡患者,主要并发症发生率差异均无统计学意义(P＞0.05).试验组体外循环和主动脉阻断时间、胺碘酮和临时起搏器应用比例,以及术后住院时间明显高于对照组(P＜0.001).随访时间6个月至3年,两组在随访期内均未出现死亡及新发脑卒中患者.6个月后两组窦性心律比例、药物免除率差异均无统计学意义(P＞0.05);左心房和左心室内径、左心室射血分数均较术前明显改善;术后3年试验组患者心房功能均得到恢复.两组患者心功能均恢复为NYHA Ⅰ级.结论 迷宫Ⅲ手术未增加二尖瓣成形术的风险,而且近中期疗效与非房颤的患者二尖瓣成形术后疗效类似.

abstractsObjeetive We sought to compare the safety and efficacy of cut-and-sew Cox-maze Ⅲ procedure for atrial fi brillation associated with degenerative mitral regurgitation,by comparing with patients without atrial fibrillation.Methods From May 2013 to November 2015,217 patients underwent mitral valve repair were enrolled,including 145 without atrial fibrillation(control group) and 28 received concomitant cut-and-sew Cox-maze Ⅲ procedure (treatment group).Propensity scores were calculated on the basis of 16 known preoperative factors and yielded the best matched patients.Safety and outcomes were compared between the two matched groups.Results 28 pairs of patients were matched successfully.No hospital deaths occurred and the major complications showed no statistical differences (P ＞ 0.05).Cardiopulmonary bypass time and crossclamp time,proportion of amiodarone use and temporary pacemaker use,and postoperative hospital stay in the treatment group were higher than those in the control group(P ＜0.001).Patients were followed up from 6 months to 3 years,and no patients occurred deaths and strokes.After 6 months,there were no significant differences in the rates of sinus rhythm and drug free between the two groups (P ＞ 0.05).In both groups,left atrial diameter and left ventricular diameter decreased,and ejection fraction increased compared with those before operation.Atrial function in the treatment group recovered 3 years after operation.At the latest follow-up,patients in both groups were all at NYHA functional class Ⅰ.Conclusion The additional cut-and-sew Cox-maze Ⅲ procedure for treatment of degenerative mitral disease complicated by atrial fibrillation does not increase the operative risks of mitral valve repair,and had early and mid-term outcomes similar to that of patients without atrial fibrillation.