摘要目的 探讨食管癌根治性放化疗(definitive chemoradiotherapy,dCRT)后挽救性外科手术的安全性和有效性.方法 回顾性分析上海交通大学附属胸科医院胸外科单一手术组2014年12月至2017年3月间连续收治的18例dCRT后行挽救性手术的食管癌患者临床及病理资料,结合随访进行分析.结果 男16例,女2例;年龄50～72岁,中位年龄56岁;dCRT结束距离手术2～18个月,中位数4个月;dCRT后肿瘤复发6例,肿瘤持续存在12例;全组dCRT后行挽救性手术的食管癌患者均采用McKeown术式并行胸腹两野淋巴结清扫,其中胃代食管15例和结肠代食管3例.根治性切除(R0)12例,姑息性切除(R2)6例,术后病理提示病理完全缓解(pCR)4例;术后并发症11例,其中肺部感染6例,吻合口瘘4例,切口感染2例,呼吸功能不全1例,喉返神经麻痹1例,乳糜胸1例,脓胸致主动脉出血1例;围手术期死亡1例(脓胸致主动脉出血).随访时间2～ 26个月,中位随访时间9个月,截至最后1次随访日期存活13例,死亡5例.除外围手术期死亡1例,分别有2例死于局域性复发转移和远处转移.结论 挽救性手术是食管癌dCRT后肿瘤复发或者持续存在的一种治疗选择.手术并发症发生比例高,dCRT后准确临床分期尤为重要,应避免ycT4、ycN+等容易出现R2切除的患者.R0切除及较长的无瘤期后再复发是预后良好的因素.

abstractsObjective To investigate the safety and efficacy of definitive chemoradiotherapy(dCRT) in esophageal cancer.Methods A retrospective analysis of 18 consecutive cases ofsalvage esophagectomy after dCRT by the single operation groupin department of Thoracic surgery,Shanghai chest hospital affiliated to Shanghai Jiaotong University from December 2014 to March 2017.Results 16 males and 2 females.There were 6 cases and 12 cases of recurrent and persistent tumor after dCRT respectively.All the patients were treated with McKeown operation stytle combing thoracic and abdominal lymph nodes dissection.Esophagus was replaced by stomach of 15 cases and colon of 3 cases respectively.Radical resection (R0) was performed in 12 cases,palliative resection (R2) in 6 cases.There were 4 cases of pathological complete response (pCR).The incidence of postoperative complications was 11 cases,including 6 cases of pulmonary infection,4 cases of anastomotic leak,2 cases of incision infection,one case of respiratory insufficiency,one case of recurrent laryngeal nerve paralysis,one case of chylothorax,one case of aortic bleeding caused by empyema.One patient died in perioperative period because of aortic bleeding due to empyema.The follow-up period was from 2 to 26 months,and the median follow-up time was 9 months.There were 13 patients survived and 5 patients died at the last follow-up date including one death in perioperative period,2 cases died of local-regional recurrence and metastasis respectively.Conclusion Salvage esophagectomy is a treatment option for the recurrent or persistent disease after dCRT,but the incidence of postoperative complications is high.Accurate clinical staging is especially important after dCRT and ycT4,ycN + patientsshould be avoided.R0 resection and recurrence after long disease free period are favorable prognostic factors.