摘要目的 研究肠三叶因子(trefoil factor 3,TFF3)在食管癌术后胃肠道功能衰竭时的表达,探讨tff3对食管癌术后胃肠道功能衰竭的早期诊断、治疗及预后意义.方法 ELISA双夹心抗体法结合酶标仪检测食管癌术后患者不同时期血清中TFF3含量.结果 食管癌术后胃肠道功能衰竭患者未发生胃肠道功能衰竭前,血清中TFF3表达较阴性对照组及无胃肠道功能衰竭组显著升高(P＜0.01);TFF3在食管癌术后发生胃肠道功能衰竭时的表达与细化的胃肠道功能评分呈负相关(r=-0.712);Cox风险比例模型检验提示,术后发生胃肠道功能紊乱或衰竭时病程时间及预后受各种因素影响.其中发生胃肠道功能衰竭时TFF3浓度(r=1.443),发生胃肠道功能衰竭48 h后TFF3浓度(风险因子=1.872,)的高表达可缩短胃肠道功能衰竭时病程时间改善预后.结论 TFF3在胃肠道功能衰竭的预测及胃肠道功能衰竭时黏膜保护及修复过程中发挥了重要的作用.

abstractsObjective To evaluate the relationship between the Trefoil factor 3 (TFF3) serum,concentration and gastrointestinal failure(GIF) and discuss eaely diagnosis,treatment and prognosis in patients with GIF after esophageal cancer surgery.Methods To test the TFF3 levels of the serum during the postoperation of esophageal cancer by ELISA.Results Serum TFF3 concentrations measured prior to the occurrence of GIF were significantly higher than in control group (P ＜ 0.01).serum TFF3 concentration was significantly related to gastrointestinal tract function score(r =-0.712).Cox proportional hazards model analysis showed that the serum TFF3 concentrations at the time of occurrence of gastrointestinal failure,and 48 hours later,could be used as prognostic factors in critically ill pediatric patients with GIF(r =1.443 and 1.872,respectively).Conclusion TFF3 may play an important role in predicting GIF in pediatric critical illness and has a protective function in the mucosal repair process.