换一批重视潜质未定的克隆性造血和意义未定的克隆性血细胞减少症的诊断和治疗
The state of the art: diagnosis and therapeutic interventions of clonal hematopoiesis of indeterminate potential and clonal cytopenias of undetermined significance
摘要2022年提出的造血淋巴肿瘤WHO分型（WHO 2022）以及髓系肿瘤和急性白血病国际共识分型（ICC）已将潜质未定的克隆性造血（CHIP）和意义未定的克隆性血细胞减少症（CCUS）正式列入了髓系肿瘤分型。最近又相继提出了三个CHIP和CCUS髓系肿瘤转化分险的预测模型，并已开展了CHIP和CCUS干预治疗临床试验。为了规范CHIP和CCUS的诊断和治疗，本文就目前我国面临的挑战以及可能的解决方案做了探讨。
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abstractsClonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS) are included in both fifth edition of the World Health Organization classification (WHO 2022) and International Consensus Classification (ICC). Recently three models were developed for prediction of myeloid neoplasms risk and clinical trials are initiated to investigate potential treatments for CHIP and CCUS. Challenges in diagnosis and therapeutic intervention of CHIP and CCUS were discussed.
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关键词
克隆性造血潜质未定的克隆性造血意义未定的克隆性血细胞减少症诊断治疗Clonal hematopoiesisClonal hematopoiesis of indeterminate potentialClonal cytopenias of undetermined significanceDiagnosisTreatment
栏目名称
DOI
10.3760/cma.j.cn121090-20241228-00600
发布时间
2025-01-14（万方平台首次上网日期，不代表论文的发表时间）
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