摘要[目的]观察慢性中心性浆液性脉络膜视网膜病变(CSC)患者患眼和对侧健眼的黄斑部脉络膜厚度.[方法]连续的慢性CSC患者45例纳入研究.其中,男性36例,女性9例；单眼39例,双眼6例.平均年龄(46.18±8.20)岁;平均病程(16.34±7.23)个月.散瞳后前置镜眼底检查,荧光素眼底血管造影和吲哚青绿血管造影检查确诊,分为CSC患眼组(A组)、单眼CSC患者对侧健眼组(B组),分别为51、39只眼.选择同期年龄、性别、屈光度匹配的正常人50名50只眼作为正常对照组(C组).采用海德堡Spectralis频域光相干断层扫描(OCT)对所有受检者行加强深度扫描,测定中心凹下脉络膜厚度(SFCT)和距中心凹3 mm处鼻侧(NCT3mm)、颞侧(TCT3mm)、上方(SCT3mm)和下方脉络膜厚度(ICT3mm).[结果]A、B、C组平均SFCT值分别为(436.76±87.01)、(394.71±61.63)、(294.86±75.30)μm.A、B组平均SFCT值均较C组平均SFCT值明显增加,三组间平均SFCT值比较,差异有统计学意义(F=44.791,P＜0.00l).三组间NCT3mm (F=15.816)、TCT3mm(F=22.823)、SCT3mm(F=15.147)和ICT3mm(F=11.527)平均脉络膜厚度值比较,差异均有统计学意义(P＜0.001).单眼者患眼平均SFCT值为(416.34±79.44) μm,较对侧健眼明显增厚,差异有统计学意义(t=2.897,P=0.007).[结论]CSC患眼脉络膜厚度明显增加,对侧健眼脉络膜厚度亦较正常对照者明显增厚.

abstracts[Objective] To observe the choroidal thickness of patients with chronic central serous chorioretinopathy (CSC) in affected eyes and unaffected fellow eyes,[Methods] Forty-five chronic CSC patients diagnosed by fundus pre-set lens,fundus fluorescein angiography (FFA) and indocyanine green angiography were enrolled in this study.The patients included 36 males and nine females,with a mean age of (46.18±8.20) years,with a mean duration of (16.34±7.23) months.Thirty-six patients were affected unilaterally and nine patients affected bilaterally.The patients were divided into affected eyes group (group A,51 eyes) and unaffected fellow eyes group (group B,39 eyes).Fifty age-,sex-and diopter-matched normal subjects (50 eyes) were enrolled in this study as control group (group C).Enhanced depth imaging (EDI) choroidal scans were obtained in all eyes by using spectral-domain optical coherence tomography.Subfoveal choroidal thickness (SFCT) and choroidal thickness at 3 mm nasal (NCT3mm),temporal (TCT3mm),superior (SCT3 m),inferior (ICT3 mm) to the fovea were measured.[Results] The mean SFCT of group A,B and C were (436.76 ± 87.01),(394.71± 61.63),(294.86 ± 75.30) μm respectively.The mean SFCT of group A and B were thicker than group C,the difference was significant among three groups (F=44.791,P＜0.001).There were difference between group A,B,C in NCT3mm,TCT3 m,SCT3mm and ICT3mm (F=15.816,22.823,15.147,11.527; P＜0.001).The mean SFCT in affected eyes of unilateral patients was (416.34 ±79.44) μm,which was thicker than that in unaffected fellow eyes (t=2.897,P=0.007).[Conclusion] Choroidal thickness increased significantly in affected eyes and unaffected fellow eyes in patients with chronic CSC.