摘要奥克纤溶酶是保留酶活性片段的重组丝氨酸蛋白酶类的纤溶酶,为强效的胶原蛋白水解酶激活剂.前期的动物及临床实验以及新近的临床应用研究表明,奥克纤溶酶玻璃体腔注射治疗玻璃体黄斑粘连(VMA)、玻璃体黄斑牵引(VMT)及全层黄斑裂孔等玻璃体黄斑界面疾病显示出较好的应用效果.目前已获得美国食品及药物管理局批准用于治疗有症状的VMA,获得欧洲药品管理局批准可用于治疗VMT并发的直径≤400 μm的黄斑裂孔.自上市以来,奥克纤溶酶的有效性、安全性以及临床应用适应证和其他值得注意的问题均有待更多的随机对照临床试验进一步全面观察与评估.

abstractsAs a potent collagenase activator,ocriplasmin is a recombinant truncated form of serine protease that retains the protease activity of plasmin.Pre-clinical animal experiments,clinical trials and recent clinical studies all indicated a promising outcome of intravitreal injection of ocriplasmin to treat vitreomacular interface diseases,including vitreomacular adhesion (VMA),vitreomacular traction (VMT) and full-thickness macular hole.Ocriplasmin was approved by the Food and Drug Administration of USA in the management of symptomatic VMA,and by the European Medicines Agency in treating VMT-associated macular hole with less than or equal 400 pm.Further randomized controlled clinical trials are needed for further comprehensive observation and evaluation on its efficiency,safety and other noteworthy issues.