摘要目的 观察玻璃体切割手术(PPV)联合硅油填充对眼表泪膜稳定性的影响.方法 临床观察型研究.行PPV联合硅油填充手术的玻璃体积血及视网膜脱离患者36例72只眼纳入研究.手术眼、对侧眼分别设为手术组、对照组,均为36只眼.手术后7、30、60、90 d行泪膜破裂时间(BUT)、基础泪液分泌试验(SⅠT)、角膜荧光素染色(CFS)检查.两组受检眼手术后不同时间点BUT、SⅠT、CFS差异行成组设计资料两样本均数比较t检验.结果 手术后7、30 d,与对照组受检眼比较,手术组患眼SⅠT分泌量增加、CFS着色点增多、BUT缩短,差异均有统计学意义(t=1.78,P＜0.05);手术后60、90 d,SIT分泌量、CFS着色点、BUT与对侧眼比较,差异均无统计学意义(t=12.39,P＞0.05).结论 PPV联合硅油填充手术早期可影响手术眼泪膜稳定性;手术后60 d可恢复至手术前水平.

abstractsObjective To observe the effect ofvitrectomy (PPV) combined with silicone oil filling on the stability of the tear film.Methods A total of 72 eyes of 36 patients with vitreous hemorrhage and retinal detachment were enrolled in the study with PPV combined with silicone oil filling.The operation and contralateral eyes were set up in the operation group and the control group respectively,each had 36 eyes.The tear film rupture time (BUT),the base tear secretion test or Schirmer Ⅰ test (S Ⅰ T) and corneal fluorescein staining (CFS) were performed at 7,30,60,and 90 days after operation.The difference of BUT,S Ⅰ T and CFS at different time points after the operation of the two groups were compared.Results After operation 7,30 days,S Ⅰ T and CFS increased,BUT staining is shortened in the surgery group,the differences were statistically significant (t=1.78,P＜0.05);after operation 60,90 days,S Ⅰ T,CFS,BUT were same between the surgery group and the contralateral eyes (t=12.39,P＞0.05).Conclusion PPV combined with silicone oil filling can affect the stability of the tear film,which can be recovered to the preoperative level at postoperative 60 days.