摘要Slit是在果蝇中枢神经系统中发现的一类分泌型糖蛋白,Robo(Roundabout)蛋白为其受体.Slit-Robo信号在神经轴突导向、炎症反应、肿瘤转移以及血管生成等方面有着重要作用.Slit2是Slit蛋白家族的一个亚型,其在血管生成方面的作用受到广泛关注,且其对血管生成方面是促进还是抑制作用仍具争议.了解Slit2-Robo信号在眼底及其他血管生成的研究进展,可为探究其机制以及寻找治疗眼底新生血管的新靶点提供线索.

abstractsAxon guidance molecules,slit glycoprotein (Slit) and Roundabout receptors (Robo) were firstly identified in the central neural system of Drosophila melanogaster.The Slit-Robo signal plays a crucial role in axon guidance,inflammation,tumor metastasis and angiogenesis,of which the role of Slit2-Robo pathway in angiogenesis has drawn a greater attention and still remains conflicting.Herein,we provide a review on the role of Slit2-Robo pathway in ocular angiogenesis and vascularization of other organs and systems.We hope this review will be the basis of further study on the mechanism of Slit2-Robo signaling on angiogenesis and provide new target for the therapy on ocular vascular disease