摘要视网膜退行性病变主要包括老年性黄斑变性、视网膜色素变性、Stargardt病等.虽然其表现形式略有差异,但其发病机制均为光感受器细胞和(或)视网膜色素上皮(RPE)细胞损伤变性.因视网膜光感受器细胞和RPE细胞缺乏自我修复和更新的能力,细胞替代疗法成为治疗该类疾病积极有效的方法之一.目前用于治疗视网膜退行性病变的干细胞有胚胎千细胞(ESC)和多种成体干细胞,如视网膜干细胞(RSC)、诱导多能干细胞(iPSC)、间充质干细胞(MSC)等.了解目前ESC、iPSC、RSC、MSC相关基础和临床应用进展,可为视网膜退行性病变治疗提供全新的思路.

abstractsRetinal degeneration mainly include age-related macular degeneration,retinitispigmentosa and Stargardt's disease.Although its expression is slightly different,its pathogenesis is photoreceptor cells and/or retinal pigment epithelial (RPE) cel 1 damage or degeneration.Because of the 1 ack of self-repairing and renewal of retinal photoreceptor cells and RPE cells,cell replacement therapy is one of the most effective methods for treating such diseases.The stem cells currently used for the treatment of retinal degeneration include embryonicstem cells (ESC) and various adult stem cells,such as retinal stem cells (RSC),induced pluripotent stem cells (iPSC).and mesenchymal stem cells (MSC).Understanding the currentbasic and clinical application progress ofESC,iPSC,RSC,MSC can provide a new idea for the treatment of retinal degeneration.