间充质干细胞外泌体:眼部给药的可选择载体
Mesenchymal stem cells derived exosomes:an alternative drug carrier for eye disease
摘要间充质干细胞(MSC)广泛应用于包括眼科在内的多种疾病治疗研究.近年研究表明,MSC外泌体具有与MSC类似的生物学功能,可替代MSC用于多种疾病治疗.外泌体是一类纳米级的具有脂质双分子层结构的小囊泡,可以介导细胞与细胞之间信号传导,发挥多种生物学功能.由于外泌体特殊的生物学结构,可穿越生物屏障,因而有望作为药物载体实现靶向运输,成为眼部给药的可选择载体.
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abstractsMesenchymal stem cells (MSCs) are considered as an ideal treatment for multiple diseases including ocular disease.Recent studies have demonstrated that MSCs-derived exosomes have similar functions with MSCs.Exosomes are nanovesicles surrounded by a phospholipid layer that shuttle active cargo between different cells.They are capable of passing the biological barrier and have potentials to be utilized as natural carrier for the ocular drug delivery.
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