摘要目的 分析河南省农村成年人静息活动时间与2型糖尿病(T2DM)发病间的关系.方法 在河南省郑州市侯寨和焦作市乔庙乡两地招募1227名成年人作为研究对象,进行问卷调查、体格检查和生化指标检测,根据是否患T2DM将研究对象分为病例组和对照组.采用Pearson线性相关和线性回归模型分析静息活动时间和FPG的关联,采用多因素logistic回归模型分析静息活动时间与T2DM的关联性.结果 研究对象FPG为(5.4±2.5)mmol/L,静息活动时间为(234.5±156.5)min/d;静息活动时间为0~<2.5、2.5~<4.5、4.5~<6.5和≥6.5 h/d的研究对象T2DM患病率分别为15.8%(72/457)、19.3%(73/379)、16.7%(35/210)和20.4%(37/181).静息活动时间(x)和FPG(y)之间存在线性回归关系,线性回归方程为:y=5.081+0.001x(t=3.01,P=0.003).调整性别、年龄后,与0~<2.5 h/d组相比,静息活动时间≥6.5 h/d者T2DM的患病风险增加77%(OR=1.77,95%CI:1.11~2.81);按性别和年龄分层后,仅在男性和≥50岁成年人中静息活动时间与T2DM存在关联,与0~<2.5 h/d组相比,静息活动时间≥6.5h/d患T2DM的风险分别增加134%和122%,OR(95%CI)值分别为2.34(1.21~4.52)、2.22(1.19~4.16).结论 较长的静息活动时间是T2DM的危险因素.按性别和年龄分层后,仅在男性和≥50岁成年人中,静息活动时间与T2DM存在关联性.

abstractsObjective To explore the relationship between the time of sedentary behaviors and the risk of type 2 diabetes mellitus (T2DM) among rural adults in Henan Province. Methods A total of 1227 adults from Houzhai village in Zhengzhou City and Qiaomiao village in Jiaozuo City in Henan Province were randomly selected to participate in the survey; each of them finished a questionnaire and accepted physical examination and test of biochemical indicators. The participants were divided into case and control groups according to whether suffering from T2DM. A Pearson linear correlation and linear regression model analysis were used to investigate the relevance between the time of sedentary behaviors and fasting plasma glucose (FPG); meanwhile, a multi factor logistic regression model was used to analyze the relationship between the time of sedentary behaviors and T2DM. Results The average FPG level among the participants was (5.4± 2.5) mmol/L, and the average time of sedentary behaviors was (234.5±156.5) min per day. The prevalence rate of T2DM in subgroups whose time of sedentary behaviors were separately 0-<2.5, 2.5-<4.5, 4.5-<6.5 and ≥6.5 h/day were 15.8% (72/457), 19.3% (73/379), 16.7% (35/210) and 20.4% (37/181), respectively. There was a linear regression relationship between the time of sedentary behaviors(x) and FPG(y), the regression equation was: y=5.081+0.001x (t=3.01, P=0.003). Logistic regression model analysis showed that participants whose time of sedentary behaviors ≥6.5 h/day had significantly higher risk of T2DM than those whose time of sedentary behaviors between 0-2.4 h/day (OR=1.77, 95%CI: 1.11-2.81) after age and gender adjusted. However, the associations only exist in males and adults ≥50 years old according to sex and age stratification. It showed that participants with sedentary time ≥6.5 h /day had significantly higher risk of T2DM than those with sedentary time between 0-<2.5 h/d, with the corresponding OR (95%CI) at 2.34 (1.21-4.52) and 2.22 (1.19-4.16), respectively. Conclusion The prolonged sedentary time is a risk factor of type 2 diabetes. After stratification by gender and age, the correlation only found in males and adults aged ≥50 years old.