摘要目的 分析2000—2014年中国肿瘤登记地区前列腺癌发病趋势及年龄变化情况.方法 选取全国具有2000—2014年连续登记数据的肿瘤登记点,对上述登记点的肿瘤监测数据进行审核、整理,最终共纳入22个登记点的监测数据,覆盖男性人口314330648人年.提取数据库中《国际疾病分类(第10版)》(ICD-10)编码为C61的全部前列腺癌患者的发病信息,计算各年份前列腺癌患者发病率、中国人口标化发病率(中标率)、年均变化百分比(AAPC)、标化平均发病年龄,按地区、年龄组分层后描述各年份发病率.利用线性回归模型分析平均发病年龄与年份间的相关性.结果 我国肿瘤登记地区前列腺癌发病率由2000年的4.62/10万上升至2014年的21.62/10万,AAPC为11.5％(95％CI:10.3％～12.7％);标化人口年龄结构后,前列腺癌的中标率仍呈上升趋势,AAPC为7.1％(95％CI:6.0％～8.1％),其中城市地区AAPC为6.5％(95％CI:5.6％～7.3％),农村地区AAPC为12.7％(95％CI:10.5％～15.0％).50岁及以上年龄别发病率呈上升趋势,且在年龄相同但出生年份不同的人群中,发病率会随着出生年份的增加而上升.2000年中国肿瘤登记地区前列腺癌的标化平均发病年龄为74.09岁,2014年为72.35岁,下降了0.13岁(β=-0.13,P<0.001);城市地区标化平均发病年龄也随年份的增加而下降(β=-0.13,P<0.001).结论 2000—2014年我国肿瘤登记地区前列腺癌发病率呈上升趋势,而发病年龄随年份增加有所降低.

abstractsObjective To analyze the trend of cancer incidence and age changes among men in cancer registration areas of China from 2000 and 2014. Methods We select the information of national cancer registry with continuous data from 2000 to 2014, review and organize the monitoring data at the above registries. A total of 22 monitoring registries were included in this study. The covering population of male were about 314330648 person years. The information on the incidence of all male prostate cancer patients with C61 was extracted from the International Classification of Diseases-10th Revision (ICD-10). To understand the incidence of male prostate cancer in each year, the age-standardized rate by Chinese population (ASR), average annual percent change (AAPC), adjusted mean age at onset were calculated. Incidence rates stratified by regions and age groups were also calculated. The linear regression model was employed to analyze the relationship between mean age at onset and year. Results The prostate cancer incidence in China increased by 11.5％(95％CI:10.3％-12.7％) from 2000(4.62/100000) to 2014(21.62/100000), the age-standardized incidence rate increased by 7.1％ (95％CI: 6.0％-8.1％) and the growth of rural was greater than that of urban. The age-specific incidence showed that the incidence rate increased significantly among the age group of 50 years;the incidence rates in men who have the same age but with different birth years showed a significant increase as birth years increased. The adjusted mean age at diagnosis of prostate cancer in cancer registry areas was 74.09 years old in the year of 2000, reduced by 0.13 year old to 72.35 years old in 2014 (β=-0.13,P<0.001). The adjusted mean age at onset declined significantly over time in urban areas (β=-0.13, P<0.001). Conclusion The trend of prostate cancer incidence among men in cancer registry regions generally increased, and the average age at diagnosis declined slightly from 2000 to 2014.