摘要目的 分析2000-2012年北京市户籍居民肺癌发病的年龄、性别及城郊分布的时间变化趋势.方法 根据北京市肿瘤登记处收集的2000-2012年肺癌新发病例,计算不同年度发病率,发病年龄的平均值、中位数根据Segi's世界人口结构计算标准化发病率(世标率).利用Joinpoint软件,计算年度平均变化率(APC),分析肺癌发病性别比和城郊比的时间变化趋势.结果 2000-2012年北京市户籍居民新发肺癌合计81 378例,发病率为52.67/10万.发病率呈上升趋势,由2000年的38.99/10万上升至2012年的65.33/10万,年平均增长4.84%(P＜0.001),世标率由2000年的27.77/10万升高到2012年的32.39/10万,APC为1.69%(P＜0.001).城区世标率由2000年的29.71/10万升高到2012年的30.55/10万,APC为0.54%(P=0.029),郊区世标率由24.02/10万升高到35.79/10万,APC为3.93%(P＜0.001),发病城郊比由1.24降低到0.85,年平均降低3.29%(P＜0.001).男、女比例由1.84降低到1.69,年平均降低0.45%(P=0.019).2000-2012年北京市男性平均发病年龄由66.27岁升高到68.97岁,平均每年升高0.23岁(P＜0.001);女性发病年龄由66.00岁升高到69.11岁,平均每年升高0.29岁(P＜0.001).结论 2000-2012年北京市城区肺癌发病率轻微增长,而郊区发病率的增长较明显,城郊比呈下降趋势.肺癌发病年龄的平均值逐年升高,但是各年龄组的时间变化趋势不同.肺癌发病的男女性别比呈下降趋势.

abstractsObjective To analyze the temporal trends of lung cancer incidence between age, gender (male and female) and areas (urban and rural) in Beijing during 2000-2012. Methods The lung cancer cases were collected by Beijing cancer registry between 2000 and 2012. We calculated the incidence and world age-standardized incidence rates (ASR) which standardized by World Segi's population. Also, the average age and median age of lung cancer incidence were calculated. The annual percent changes (APC) for the whole period, for the gender ratio and for the area ratio were evaluated with Joinpoint analysis. Result Totally, 81 378 new cases of lung cancer were diagnosed in 2000-2012 with the average incidence rate of 52.67/100 000. The incidence rate increased by 4.84% per year from 38.99/100 000 to 65.33/100 000, but the APC of ASR was 1.69%(P＜0.001). The ASR increased 0.54%(P=0.029)per year in urban from 29.71/100 000 to 30.55/100 000 and 3.93%(P＜0.001)in rural areas from 24.02/100 000 to 35.79/100 000. The incidence ratio of urban to rural decreased from 1.24 to 0.85 (APC=-3.29%, P＜0.001). The incidence ratio of male to female decreased from 1.84 to 1.69 (APC=-0.45%, P=0.019).The average age of lung cancer incidence of male and female increased from 66.27 and 66.00 to 68.97 and 69.11(P＜0.001), respectively. Conclusion The incidence rate of lung cancer increased slightly in urban areas but increased significantly in rural areas during 2000-2012, the area ratio trend was declined. The average age of lung cancer occurrence gradually increased, but the temporal trends varied with age group. The gender ratio decreased from 2000 to 2012.