摘要对硫胺素响应性巨幼细胞贫血综合征（thiamine-responsive megaloblastic anemia syndrome，TRMA）研究领域的现状、研究热点、演变趋势和未来展望进行可视化分析，为TRMA发病机制的后续研究与防治策略提供新的思路和方向。本研究以Web of Science核心数据库为文献来源，以1997—2023年间发表的TRMA相关文献记录为研究对象，利用R软件及Citexs数据库对研究内容进行可视化分析和讨论。结果显示，1997—2023年共发表相关文献89篇，文献年均发文量3篇。按国家分类，发现美国和以色列等国家和机构发表论文较多。通过关键词频率分析，糖尿病、耳聋、硫胺素响应性巨幼细胞贫血及溶质载体家族19成员2（SLC19A2）基因突变等关键词出现的频率高，表明至今以上述关键词作为主要研究方向，凸显了对TRMA的机制探索逐渐达成共识。综上，当前TRMA以糖尿病、耳聋、硫胺素响应性巨幼细胞贫血等为研究热点，而核心基因SLC19A2的研究可能成为未来分子研究的新突破点。

abstractsVisual analysis of the current status, research hotspots, evolving trends, and future prospects in the field of thiamine-responsive megaloblastic anemia syndrome (TRMA), providing new insights and directions for subsequent research on the pathogenic mechanisms and prevention strategies of TRMA. Taking the core database of Web of Science as the literature source, selecting TRMA-related literature records published from 1997 to 2023 as the research object, and using R software and Citexs database to conduct visual analysis and discussion of the research content. The results showed that a total of 89 publications related to the topic were published from 1997 to 2023, with an average annual publication volume of 3 papers. Classified by country, it was found that the United States, and Israel among other countries and institutions, published a significant number of papers. Through keyword frequency analysis, high frequencies of keywords such as diabetes, deafness, thiamine-responsive megaloblastic anemia, and mutations in the solute carrier family 19 member 2 (SLC19A2) gene were observed, indicating that to date, these keywords have been the main research directions, highlighting a gradually reached consensus on the mechanism exploration of TRMA. In conclusion, TRMA research focuses on the mechanisms of hot topics such as diabetes, deafness, and thiamine-responsive megaloblastic anemia, and the core gene SLC19A2 research may currently become a new breakthrough point for future molecular studies.