摘要视神经损伤是眼科重要的致盲因素之一,目前临床尚无特效的治疗方法.神经营养因子可明显促进视网膜神经节细胞的存活和轴突的再生,但其在体内的作用时间较短.通过转基因技术持续表达神经营养因子则克服了这一缺点,这将为治疗视神经损伤性疾病提供新思路.笔者就近年来国外应用神经营养因子转基因技术治疗视神经损伤的研究进展进行综述,以供同道参考.

abstractsOptic nenre injury is one of factors leading to blindness,and the effective thempy is still not available in clinic.The neurotrophic factors (NTF) can significantly enhance the survival of retinal ganglial cells (RGC) and the regeneration of axonal but showed a short-term effect in vivo.The continue expression of NTF by transgenic technology could overcome this disadvantage,which may provide a new therapeutic approach for the optic nerve injury.We reviewed the articles regarding the research progress of transgenic technology in the treatment of optic nerve injure by NTF recently.