摘要角膜对温度、机械和化学等刺激的感受依赖于各种伤害性感受器。早年，对该过程的认识一度停留于神经生理学层面，即以传递相同信号的神经纤维束来划分。随着近年分子生物学技术和方法的发展，伤害性感受器的分类与功能已精确到细胞感受器水平，即各类通道蛋白。其中，瞬时受体电位(Transient Receptor Potential，TRP)离子通道蛋白超家族占有重要地位。已发现多个TRP家族成员在角膜中表达，并参与了角膜疼痛、神经源性角膜病、上皮损伤修复、免疫炎症反应等过程，部分TRP受体甚至成为潜在的治疗靶点。

abstractsCornea senses thermal, mechanical and chemical stimuli via various nociceptors. In the early years, knowledge of the mechanism of corneal nociception was merely restricted to neurophysiology,which classifies nociceptors according to the clusters of nerve fibers which transmit identical stimulation signals. During the past decade, benefiting from the promptly developing molecular biology and technology,classification of the nociceptors has been modified into the level of cell sensors, among which, transient receptor potential (TRP) channel superfamily weighs the most. Researches have shown that there are a couple of TRP superfamily members expressed in cornea, which play major roles in the process of corneal pain, neurotrophic keratopathy, epithelial wound healing and immuno-inflammation. Some TRPs have even been recognized as targets of management of keratopathy.