摘要目的：评价选择性激光小梁成形术（ SLT）或前列腺素衍生物（ PGA）治疗开角型青光眼（ OAG）及高眼压症（ OHT ）的疗效。方法文献分析。通过计算机检索 Medline （1966年1月至2012年12月），EMBASE Reviews （1974年1月至2012年12月），OVID循证医学数据库、中国生物医学文献数据库 SinoMed （1978年1月至2012年12月）及 CNKI 数据库（1999年1月至2012年12月），并采用手工检索等方法收集会议文献，纳入所有相关随机对照试验。评价所纳入研究的方法学质量后，采用RevMan 5.0软件进行Meta分析。结果共纳入3个随机对照试验，161例（231只眼）开角型青光眼或高眼压症患者。 Meta 分析结果表明，SLT组降低眼压值较PGA组少0.85 mmHg [1 mmHg＝0.133 kPa；WMD＝-0.85，95％CI（-1.43～-0.27）；P＝0.82，I2＝0％]；治愈成功率两组相当[OR＝0.70，95％CI＝（0.49～1.19）；P＝0.58，I2＝0％]；PGA组需要补充治疗的患眼所占比例较SLT组大[OR＝1.11，95％CI（0.60～2.06）；P＝0.08，I2＝61％]。结论对于开角型青光眼或高眼压症的初始治疗，SLT与PGA治疗成功率相当；SLT降低眼压值幅度较单一PGA小，与PGA相比，SLT可以减少患者抗青光眼药物的使用种类。（中华眼科杂志，2014，50：343-348）

abstractsObjective To compare the efficacy of selective laser trabeculoplasty ( SLT ) versus prostaglandinanalogue ( PGA) in the treatment of open angle glaucoma ( OAG) and ocular hypertension ( OHT) . Methods Literature analysis.Systematic review of randomized controlled trials comparing SLT versus PGA , identified by searching literatures including Medline (January,1966-December, 2012), EMBASE Reviews ( January , 1974-December , 2012 ) OVID Evidence-Based Medicine Reviews ( January , 1966-December , 2012), Chinese BioMedical Literature Database SinoMed (January,1966-December, 2012), and CNKI (January,1999-December, 2012).RevMan 5.0 was used to do meta-analysis.Results Three publications reporting 3 trials, 161 participants ( 231 eyes ) with OHT or OAG were included for meta-analysis.IOP reduction favored PGA group,weighted mean difference (WMD) =-0.85 [1 mmHg=0.133 kPa;95%confidence interval (CI) ( -1.43 to -0.27), no significant heterogeneity present ( P =0.82, I2 =0%)].Success rates are equal in two groups [OR =0.70,95%CI =(0.49 to 1.19), no significant heterogeneity present (P=0.58,I2 =0%)].Eyes underwent additional antiglaumatous interventions favored SLT group,OR=1.11 [95%CI =(0.60 to 2.06), significant heterogeneity present, (P=0.08, I2 =61%) ].Conclusions As primary therapy of OAG or OHT , SLT is no more effective than PGA in success rate.IOP reduction affected by SLT is not effective than PGA.Compared with PGA , SLT can reduce the use of anti-glaucoma medications.