摘要目前局部抗炎治疗已成为临床治疗干眼的重要方法.但是由于常规抗炎药物的不良反应,使干眼长期药物治疗受到限制,因此探寻更加安全有效的通过抗炎作用治疗干眼的新手段成为必然.必需脂肪酸具有全身抗炎作用,这使该药物用于干眼治疗成为可能.临床研究证实无论单一补充ω-3或ω-6必需脂肪酸,还是两者联合使用,均显示出多方面的干眼治疗效果,即改善患者主观症状、减轻眼表与睑缘炎性反应、延长泪膜破裂时间、增加泪液分泌等.相关基础研究发现必需脂肪酸治疗干眼的机制除主要为抗炎作用外,还包括促进角膜上皮生长作用和增加泪液分泌作用.本文着重总结必需脂肪酸治疗干眼的有效性、可行性及其作用机制方面的研究进展.

abstractsTopical anti-inflammatory therapy has become the significant way of treating dry eye so far.However,as the long-term use of routine anti-inflammatory medications are restricted from their side effects,it is inevitable to explore safer and more effective alternatives.Essential fatty acids have proven to be anti-inflammatory systemically,which makes it possible to treat dry eye.Clinical trials have demonstrated that supplementation with either ωo-3 or ωo-6 essential fatty acids or both has multifactorial efficacies including improvement of subjective symptoms,alleviation of inflammation of ocular surface and eyelid margin,prolongation of tear break-up time and increase of tear flow secretion.Besides anti-inflammation effects,several basic researches have revealed that other mechanisms of essential fatty acids treating dry eye might lie in the corneal epithelial healing and tear secretion promotion.This review puts emphasis on the effectiveness,feasibility and mechanism of treating dry eye with essential fatty acids.