摘要目的 分析四川大学华西医院门诊青光眼患者的抗青光眼药物使用特点.方法 回顾性系列病例研究.从四川大学华西医院信息系统提取四川大学华西医院门诊2015年全年青光眼患者6236例(13693例次)的信息,包括日期、医嘱日期、医嘱名称、诊断、西药费、中药费等.采用Excel 2011软件对门诊青光眼患者的用药情况进行统计分析.结果 (1)四川大学华西医院门诊2015年全年青光眼用药患者13693例次,其中未使用降眼压药物者4247例次,占31.02%(4247/13693).(2)共使用降眼压药物7类14种,用药频次前3位的依次为前列腺素(PG)类衍生物(5847例次)、β-肾上腺素能受体阻滞剂(4207例次)、碳酸酐酶抑制剂(CAI)类(3312例次).(3)在降眼压药物单用或联用中,单药患者占62.41%(5895/9446),其中最常见的是PG类药物,占44.94%(2649/5895);二联用药占28.03%(2648/9446),其中"β-肾上腺素能受体阻滞剂+PG类"应用最多,占27.57%(730/2648);三联用药占7.88%(744/9446),其中"β-肾上腺素能受体阻滞剂+PG类+CAI类"最常见,占46.24%(344/744);四联用药占1.57%(149/9446),其中"β-肾上腺素能受体阻滞剂+α-肾上腺素能受体激动剂+PG类+CAI类"应用最多,占87.25%(130/149);五联用药占0.11%(10/9446).结论 在四川大学华西医院门诊2015年青光眼患者降眼压药物治疗中,单药以PG类最多,PG类药物已成为一线用药;联合用药中,二联用药以β-肾上腺素能受体阻滞剂+PG类最常见,三联用药以β-肾上腺素能受体阻滞剂+PG类+CAI类最常见.(中华眼科杂志,2018,54:189-193)

abstractsObjective To retrospectively investigate the medication structures and characteristics among the outpatients diagnosed with glaucoma at West China Hospital of Sichuan University in 2015. Methods Based on retrospective study method, the data of glaucoma patients (6 236 people, and 13 693 person-times) who received medication at the outpatient department of West China Hospital in 2015 were collected from hospital information system,such data include date,doctor's advice date,doctor's advice ID, diagnosis, western medicine fee, Chinese medicine fee, etc. Excel 2011 software was used to analyze the drug use of glaucoma outpatients. Results (1) The total of outpatients with glaucoma medication were 13 693 person-times, of which 4 247 persons-times patients who did not take intraocular pressure (IOP)-lowering drugs accounted for 31.02%.(2)There were 7 types of IOP-lowering drugs used,including 14 kinds of different drugs.The top three most frequently used drugs were prostaglandin analogs(PGA,36.98%, 5 847 cases),β-adrenergic receptor blockers(26.61%,4 207 cases),and carbonic anhydrase inhibitor(CAI, 20.95%,3 312cases). (3) Among all the patients who have taken IOP-lowering drugs, the patients that received single-drug treatment accounted for 62.41% (5 895/9 446), and the most frequently used single IOP-lowering drug is PGA(44.94%,2 649/5 895). Patients that received two-drugs combined treatment accounted for 28.03% (2 648/9 446), and the most frequently used combined treatment is"β-adrenergic receptor blockers+ PGA"(27.57%,730/2 648). Patients that received three-drugs combined treatment accounted for 7.88% (744/9 446), and the most frequently used combined treatment is"β-adrenergic receptor blockers+ PGA + CAI"(46.24%,344/744). Patients that received four-drugs combined treatment accounted for 1.57% (149/9 446), and the most frequently used combined treatment is"β-adrenergic receptor blockers+α-adrenergic receptor agonist +PGA + CAI"(87.25%,130/149). And patients that received five-druges combined treatment accounted for 0.11% (10/9 446). Conclusions The most frequently used single IOP-lowering drug for outpatients with glaucoma at West China Hospital of Sichuan University in 2015 is PGA. The most frequently used combined medications are"β-adrenergic receptor blockers+PGA"for two-drugs combined treatment and"β-adrenergic receptor blockers+PGA+CAI"for three-drugs combined treatment.(Chin J Ophthalmol,2018,54:189-193)