摘要目的 探讨扫频源前节相干光层析成像术(SS-AS-OCT)与超声生物显微镜(UBM)测量前房深度及房角参数结果的一致性.方法 前瞻性研究.选取2016年11至12月在首都医科大学附属北京同仁医院北京同仁眼科中心就诊的单纯老年性白内障患者45例(45只眼),男性23例,女性22例,年龄(51±19)岁.分别用SS-AS-OCT和UBM测量其前房深度及鼻、颞、上、下4个方位的房角参数,包括距巩膜突500μm的房角开放距离(AOD500)和小梁网-虹膜夹角(TIA500).采用配对样本t检验比较两种仪器前房深度、AOD500和TIA500的测量结果 ,采用Pearson直线相关分析法分析两种仪器测量结果的相关性,采用Blant-Altman分析评价两种仪器测量结果的一致性.结果SS-AS-OCT和UBM测得的前房深度分别为(2.750±0.544)mm和(2.775±0.531)mm,差异有统计学意义(t=2.109,P=0.040),二者测量结果呈正相关(r=0.989,P<0.001).SS-AS-OCT与UBM对鼻、颞、上、下4个方位的AOD500和TIA500测量结果差异均有统计学意义[AOD500:SS-AS-OCT检测值分别为(0.451±0.201)mm、(0.499±0.229)mm、(0.390±0.215)mm、(0.441±0.226)mm,UBM检测值分别为(0.421±0.194)mm、(0.465±0.207)mm、(0.355±0.208)mm、(0.423±0.215)mm,二者比较的t值分别为4.262、4.350、5.355、4.415;TIA500:SS-AS-OCT检测值分别为39.587°±14.698°、42.149°±14.138°、36.482°±15.887°、38.504°±14.805°,UBM检测值分别为36.944°±13.790°、40.289°±13.041°、35.600°±15.215°、36.818°±14.931°,二者比较的t值分别为5.131、4.658、4.174、5.731;均P<0.001],且二者测量结果呈正相关(AOD500:r值分别为0.971、0.975、0.979、0.973;TIA500:r值分别为0.972、0.957、0.956、0.970;均P<0.001).Blant-Altman分析显示两种测量方法有较好的一致性(2.22％～6.67％的测量值在95％的一致性界限外).结论 SS-AS-OCT与UBM在测量前房深度和房角参数中存在差别,但两者的一致性和相关性均较好.

abstractsObjective To explore the difference and agreement in the measurement of anterior chamber depth (ACD) and anterior chamber angle data in age-related cataract patients between swept source anterior segment optical coherence tomography (SS-AS-OCT) and ultrasound biomicroscopy (UBM). Methods A prospective study. Forty-five eyes from 45 age-related cataract patients were selected at Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University from November to December 2016. There were 23 males and 22 females aged (51±19) years. SS-AS-OCT and UBM were used to measure the ACD, angle opening distance (AOD 500) and trabecular-iris angle (TIA 500). The paired samples t-test and Pearson linear correlation were used for statistical analysis,and the Bland-Altman analysis was used to evaluate the measurement consistency of the two tools. Results The ACD measured by SS-AS-OCT and UBM was (2.750 ± 0.544) mm and (2.775 ± 0.531) mm, respectively, the difference was statistically significant (t=2.109, P=0.040), and the measurement results were positively correlated (r=0.989, P<0.001). In the nasal, temporal, upper and lower positions, the AOD 500 and TIA 500 values measured by SS-AS-OCT and UBM had a significant difference [AOD 500:(0.451 ± 0.201) mm vs. (0.421 ± 0.194) mm, (0.499 ± 0.229) mm vs. (0.465 ± 0.207) mm, (0.390 ± 0.215) mm vs. (0.355 ± 0.208) mm, (0.441 ± 0.226) mm vs. (0.423±0.215) mm, t=4.262, 4.350, 5.355, 4.415;TIA 500:39.587°±14.698°vs. 36.944°±13.790°, 42.149°± 14.138°vs. 40.289°±13.041°, 36.482°±15.887°vs. 35.600°±15.215°, 38.504°±14.805°vs. 36.818°±14.931°, t=5.131, 4.658, 4.174, 5.731;all P<0.001] and a significant linear correlation (AOD 500:r=0.971, 0.975, 0.979, 0.973;TIA 500:r=0.972, 0.957, 0.956, 0.970;all P<0.001). The Bland-Altman method showed that the two modalities had comparable results for the ACD, AOD 500 and TIA 500 (2.22％-6.67％ of the measured value outside the 95％ consistency boundaries). Conclusion SS-OCT and UBM show a good agreement in the measurement of ACD and anterior chamber angle data in age-related cataract patients, though there is difference between them in measurement results.