摘要目的 评估红细胞体积分布宽度(RDW)与我国急性冠状动脉综合征(ACS)患者心功能变化的关系.方法 回顾性分析228例ACS患者的基线临床数据,分别按RDW和心功能进行分类,对实验室检测指标进行比较.将血肌酐和RDW分别与左室射血分数(LVEF)进行相关分析.结果 RDW按四分位数分为4组,不同RDW组间ACS患者年龄[Q1～Q4组分别为(60±12)、(65±11)、(64±11)、(71±12)岁]、血肌酐[Q1～Q4组分别为(70±19)、(76±24)、(74±20)、(85±26)μmol/L]和LVEf[Q1～Q4]组分别为(57±9)%、(55±10)%、(53±11)%、(49±11)%]差异均有统计学意义(P=0.0000、0.0054、0.0002).心功能Ⅳ级组比Ⅰ级组患者的RDW更高(13.9%±1.2%比13.1%±5.7%,P<0.05).RDW与LVEF存在显著相关性(r=-0.30,P<0.01).结论 RDW可能与我国.ACS患者心功能存在密切的相关性.

abstractsObjective To evaluate the relationship between red cell volume distribution width (RDW) and cardiac function in acute coronary syndrome (ACS) patients. Methods We analyzed the baseline clinical data of 228 ACS patients consecutively admitted into our hospital according to the classification of RDW and NYHA function class. Correlation analysis was made respectively between RDW and plasma creatinine and left ventricular ejection fraction ( LVEF) . Results There were significant differences of age [Group Q1 to Group Q4: (60±12),(65 ±11),(64 ± 11), (71 ± 12) years old],plasma creatinine [Group Q1 to Group Q4:(70±19),(76 ±24),(74±20),(85 ±26)μmol/L] and LVEF [Group Q1 to Group Q4:(57±9)%,(55±10)%,(53±11)%,(49 ± 11)%] among different RDW groups (P =0.0000,0.0054,0.0002,respectively).Comparing to NYHA function I, patients of NYHA function IV had a higher RDW (13.9%±1.2% vs 13.1%±5.1%,P<0. 05).There were significant negative correlations between RDW and LVEF( r=-0. 30, P<0.01). Conclusion RDW may be significantly related to cardiac function in Chinese ACS patients.