摘要目的 观察左氧氟沙星(可乐必妥)针剂与片剂序贯疗法预防腹腔镜下全子宫切除术(LH)、腹腔镜辅助下阴式全子宫切除术(LAVH)及阴式全子宫切除术(TVH)围手术期感染的有效性和安全性.方法 对2009至2010年北京协和医院有指征行LH、LAVH及TVH的50例患者进行研究,年龄18～65岁;一般状况良好;术前无严重女性生殖系统感染.予以左氧氟沙星500 mg,每日1次,静脉滴注;序贯片剂500 mg,每口1次,口服.观察预防围手术期感染的有效性和不良反应.结果 平均静脉用药时间为4.3 d,序贯口服用药4.5 d.48例患者围手术期未出现感染,预防感染的有效率为96.0%;全部患者中,仅1例出现轻微胃肠道反应,不良反应发生率为2.0%.结论 左氧氟沙星针剂与片剂序贯疗法预防LH,LAVH及TVH围手术期感染的有效率高、安全性好.

abstractsObjective To investigate the effect and safety of sequential therapy of levofloxacin in the Drevention of peri-operative infections among patients undergoing laparoscopic hysterectomy(LH),laparoscopic assisted vaginal hysterectomy(LAVH)and transvaginal hysterectomy(TVH).Methods During 2009-2010,a total of 50 patients with the indications for LH,LAVH or TVH at our hospital were recruited.Their age range was 18-65 years old.In fair general conditions,they had no severe infection of female reproductive system.Levofloxacin 500 mg was administered by an intravenous injection once daily and then orallv once dailv.Results The average duration of intravenous injection of levofloxacin was 4.3 days while and the duration of its oral administration 4.5 days.No infection was seen in 48 patients with an efficient nrevention rate of 96.0%.Only l patient showed mild gastroenterological reactions.The side reaction rate was 2.0%.Conclusion The sequential therapy of levofloxacin is both effective and safe in the preyention of peri-operative infections among patients undergoing LH,LAVH and TVH.