摘要目的 探讨肝移植术后受者的生育能力及其子代生长发育状况.方法 回顾分析在中山大学器官移植中心随访的336例肝移植术后受者中13例生育受者的生育情况,用生长发育指数和丹佛发育筛查表评估其子女的生长发育状况.结果 13例受者生育了16名子女.其中2例女性受者分别生育1子1女,10例男性受者使妻子怀孕并生产6子8女,1名男性受者已使妻子怀孕28周.11例男性受者首次致孕的中位时间是术后21个月,共致孕15例次,其中12例次的平均孕龄为(38.2±1.8)周,未发生妊娠相关并发症.12名婴儿平均出生体重为(3.1 ±0.5)kg,其中早产儿3名,低体重儿2名.2例女性受者生育2名子女的孕龄分别为37.3和40.4周,出生体重分别为2.7和3.4 kg,1例出现轻度新生儿缺氧,未发生妊娠相关并发症.16名婴儿均未发现畸形.接受检测的13名子女的生长发育指数和10名子女丹佛发育筛查结果基本正常.结论 育龄肝移植术后受者可以生育,其子女的近期的生长发育状况良好.

abstractsObjective To explore the recipient's reproduction after liver transplantation (LT) and assess the outcomes of their offspring.Methods We retrospectively analyzed the reproduction status of 13 post-LT patients among 336 post-LT recipients during a follow-up period.Physical and intellectual status of their offspring were evaluated by developmental index and Denever developmental screening test. Results A total of 16 children were mothered or fathered by 13 LT patients.Two female patients mothered a boy and a girl.Ten male patients fathered 6 male and 8 female children while another male fathered a child at 28 gestational weeks.Eleven patients fathered the first gestation 21 mon (medium) since LT,and fathered 15 pregnancies.Twelve of 14 deliveries had a mean gestation age of(38.2± 1.8 )weeks,with a mean birth weight of (3.1 ±0.5)kg.Among 12 newborns,3 were premature and 2 of a low birth weight.Two female patients delivered 2 babies with a gestation age of 37.3 and 40.4 weeks,a birth weight of 2.7 and 3.4 kg,and anoxia neonatorum in one case. No deformity was found.Thirteen of 16 children had almost normal developmental indices and ten had almost normal Denever developmental screening. Conclusion Post-LT patients of reproductive age are able to reproduce offspring.The short-term development of their offspring is relatively normal.