摘要目的 探讨常见危险因素与中国北方青年前后循环缺血性脑卒中及其短期预后的关系,为临床的预防和治疗提供依据.方法 本研究人选中国北方青年缺血性脑卒中患者446例,均来自首都医科大学宣武医院神经科2001-2010年间住院患者,其中单纯前循环353例、非前循环93例；单纯后循环56例、非后循环390例；同时累及前后循环37例,非前后循环同时受累409例.用非条件Logistic回归方法分析确定预测前后循环病变发生及影响其短期预后的危险因素.结果 Logistic回归分析得出的预测因素包括:年龄增长、高白细胞计数增加非前循环病变发生风险(OR0.951,P =0.030;OR0.876,P=0.014)；饮酒史增加单纯后循环病变发生风险(OR1.856,P=0.047)；高NIHSS评分,高总胆固醇含量预示单纯前循环病变短期预后不良(OR 1.884,P=0.000;OR1.792,P=0.008).结论 年龄、白细胞计数、饮酒、NIHSS评分和总胆固醇与中国北方青年缺血性脑卒中前后循环不同部位病变的发生及短期预后不良密切相关.

abstractsObjective To explore different risk factors between anterior and posterior circulation affecting onset and prognosis in the North Chinese young ischemic stroke patients.Methods This study included 446 cases of young ischemic stroke patients in northern China.All patients were recruited from our department from 2001 to 2010,Among them,the lesion sites were anterior circulation infarction (n =353),posterior circulation infarction (n =56) and both anterior and posterior circulation infarction (n =37).Nonconditional Logistic regression analysis was used to determine the risk factors of predicting the onset of either anterior or posterior or mixed stroke and their short-term prognosis.Results Advanced age and a higher white blood cell count (WBC) increased the risk of non-anterior circulation lesions (OR 0.951,P =0.030 ;OR 0.876,P =0.014).Patients with a history of alcohol drinking had an increased risk for simple posterior circulation lesions (OR 1.856,P =0.047) ; Both high National Institute of Health stroke scale (NIHSS score) and high total cholesterol (TC) predicted a poor short-term prognosis for simple anterior circulation lesions(OR 1.884,P=0.000; OR 1.792,P=0.008).Conclusion Age,WBC count,alcohol intake,NIHSS score and TC are closely correlated with different lesions of northern Chinese young patients with ischemic stroke and their poor short-term prognosis.