摘要目的 比较周围静脉溶栓与深静脉置管溶栓治疗急性下肢深静脉血栓形成(DVT)的近期疗效与并发症,评价深静脉置管溶栓的应用价值.方法 收集2008年1月至2010年12月中国医科大学附属第一医院放射科86例DVT患者,分为周围浅静脉溶栓组(A组,33例)和深静脉置管溶栓组(B组,53例),对比两组下肢消肿率、静脉通畅率及近期并发症的差异.结果 两组消肿率比较(大腿A组59％±33％,B组66％±30％；小腿A组67％±31％,B组60％±30％),差异无统计学意义(P＞0.05).静脉通畅率比较,B组(57％±23％)优于A组(38％±26％),差异有统计学意义(P＜0.05).两组出血发生率差异无统计学意义(P＞0.05),均无症状性肺梗死发生.结论 两种溶栓方法均可有效改善急性下肢DVT症状,深静脉置管溶栓静脉通畅率高,且不增加溶栓出血概率.

abstractsObjective To evaluate the effects of catheter-direct thrombolysis in acute deep venous thrombosis (DVT).Methods A total of 86 cases were divided into 2 groups of peripheral venous thrombolysis (group A,n =33) and catheter-direct thrombolysis (group B,n =53).The curative effect of two groups was compared by swelling rate and vascular potency.Results No significant difference existed in swelling rate between two groups (P ＞0.05).Vascular patency rates of group B was significantly better than those of group A (P ＜ 0.01).The incidence of bleeding had no significant difference (P ＞ 0.05) and there was no asymptomatic pulmonary embolism in two groups.Conclusion Both treatments of acute DVT are effective in improving symptoms.But catheter-directed thrombolysis results in significant vascular patency rate and does not increase the risk of thrombolytic bleeding.