摘要目的 探讨上海社区抑郁老人与无抑郁老人认知功能的差异.方法 2011年由上海四个社区中应用SPSS统计软件随机抽样法选取老年人1 068名,由统一培训的心理测评师对所有研究对象进行测评,本研究应用老年抑郁量表(GDS-30)＞10分的102例抑郁老人作为抑郁组,并从GDS评分≤10分的无抑郁老人946例中应用SPSS软件随机抽样法选取102例无抑郁老人作为无抑郁组.认知功能评估量表应用蒙特利尔量表(MoCA).结果 抑郁组与无抑郁组比较在MoCA总分(t =2.353)、连线(t=2.236)、注意(t=2.621)、持续注意(t=2.381)、计算(t=2.612)及地点定向(t =2.259)差异有统计学意义(P＜0.05).相关结果显示MoCA总分(r=-0.142)、注意(r=-0.161)、持续注意(r=-0.160)、计算(r=-0.150)、流畅性(r=-0.156)、延迟回忆(r=-0.175)及地点定向(r=-0.172)与GDS评分均呈负相关(P＜0.05).抑郁组中有认知功能损害者与无抑郁组中有认知功能损害者比较MoCA总分[(14.9±7.3)分比(17.5±6.7)分]、注意[(1.1±0.8)分比(1.4±0.8)分]、计算力[(1.9±1.2)分比(2.3±1.1)分]及地点定向[(1.7±0.7)分比(1.8±0.5)分]差异有统计学意义(P ＜0.05或P＜0.01).结论 抑郁老人认知损害涉及多认知领域,主要表现在注意力、执行功能及地点定向方面.GDS评分与认知功能呈负相关,GDS评分越高,认知功能相对越差.

abstractsObjective To explore the characteristics of cognitive impairment in depressive elders in Shanghai.Methods A total of 1 068 participants randomly selected from 4 communities in Shanghai underwent neuropsychiatric and psychiatrists clinical assessment.Among them,102 depressive ones with a score of geriatric depression scale (GDS) ＞ 10 and 102 non-depressive ones with a score of GDS≤ 10 were selected as depression and non-depression groups respectively.The SPSS statistic software V17.0 was used.Results Significant differences existed between the depressive and non-depressive patients in the total score of Montreal Cognitive Assessment (MoCA) (t =2.353),trail making B task (t =2.236),attention (t =2.621),sustained attention (t =2.381),calculation (t =2.612) and fixed orientation (t =2.259) (P ＜0.05).The negative correlation had significant inter-group differences in the total score of MoCA (r =-0.142),attention (r =-0.161),sustained attention (r =-0.160),calculation (r =-0.150),fluency (r =-0.156),delayed recall (r =-0.175) and orientation to place (r =-0.172) (P ＜ 0.05).Cognitive impairment in depression group had lower scores than non-depression group in the total score MoCA (14.9-± 7.3 vs 17.5 ± 6.7),attention (1.1 ± 0.8 vs 1.4 ± 0.8),calculation (1.9 ± 1.2 vs 2.3 ± 1.1)and fixed orientation (1.7 ± 0.7 vs 1.8 ± 0.5) (P ＜ 0.05).Conclusion In depressive elders,cognitive impairment occurs in multiple cognitive domains of attention,executive function and orientation to place.There is a negative correlation between GDS score and MoCA.The higher GDS score,the worse cognitive function.