摘要目的 分析三阴性乳腺癌复发的特征,并与临床病理特征进行相关性分析,了解三阴性乳腺癌的预后情况.方法 统计2003年9月至2008年9月天津医科大学肿瘤医院收治的4 579例乳腺癌患者为对象,其中三阴性乳腺癌患者共787例,对其临床病理特征、复发时间和类型以及预后进行相关性分析.结果 在中位随访期72(9 ～116)个月的随访中,187例(23.8％)三阴性乳腺癌患者发生复发,与非三阴性乳腺癌组17.4％的复发率相比差异有统计学意义(P=0.024);其中位复发时间是30.2(4～110)个月,2年内发生复发的患者占36.3％,2～3年内发生复发者占27.8％.三阴性乳腺癌患者发生肺、肝、脑等转移的概率均高于非三阴性乳腺癌,且更易发生局部复发(P=0.009).三阴性乳腺癌复发转移的危险因素包括:年轻,腋窝淋巴结转移,较大的原发瘤以及较晚的临床分期.结论 三阴性乳腺癌具有其独特的复发特征,三阴性乳腺癌患者易在诊断后早期发生复发,且发生内脏转移的比例高于骨转移,同时发生局部复发的比例高.

abstractsObjective To analyze the recurrence characteristics of triple-negative breast cancer (TNBC) and explore their clinicopathological correlations in northern China.Methods Regression analyses were performed for 4 579 breast cancer patients from September 2002 to September 2007.Among them,there were 787 TNBC patients.Results The median follow-up period was 72 (9-116) months.And 187 (23.8％) TNBC patients recurred and it was significantly different from the recurrence rate of nonTNBC group (17.4％,P =0.024).The median time to recurrence was 30.2 (4-110) months and 36.3％ recurred 2 years while 27.8％ did within 2-3 years.The rates of lung,liver and brain metastases to other sites were higher in TNBC patients than those in non-TNBC patients.TNBC patients had higher local recurrence rates than non-TNBC counterparts (2.92％ vs 1.56％) (P =0.009).Age,regional lymph node infiltration,tumor size and pathological stage were all independent prognostic factors of TNBC.Conclusion TNBC has unique recurrence characteristics.It is prone to recur shortly with a high local recurrence rate.Metastatic rate is higher in visceral organ than bone.