摘要目的 对上尿路结石碎石术后运用Friend-Ⅰ型体外物理振动排石机(EPVL)辅助排石的疗效进行荟萃分析.方法 检索Pubmed、Medline、Embase、Cochrane图书馆和中国知网光盘数据库从建刊至2016年3月期间的相关文献,收集所有比较上尿路结石碎石术后运用EPVL辅助排石患者与传统排石疗法患者之间疗效差异的随机对照实验(RCT)与半随机对照实验(Quasi-RCT),评价纳入研究质量,提取有效数据,采用Review Manager5.3软件进行Meta分析.结果 根据本研究设定的纳入与排除标准,最终纳入5篇RCT与Quasi-RCT.EPVL组首日排石率明显高于对照组(OR=4.95,95％ CI:3.35 ～7.32,P＜0.000 01);EPVL组1周后(OR=3.13,95％ CI:1.95～5.04,P＜0.00001)及两周后(OR=4.50,95％ CI:2.02～ 10.00,P=0.000 2)结石排净率亦明显高于对照组.随访期间EPVL组未出现严重的不良事件.结论 现有证据支持在临床中运用EPVL协助上尿路结石碎石术后的排石治疗.然而受限于本研究较小的样本量,能否在临床中常规运用EPVL协助排石治疗仍需要更多高质量、大样本的RCT研究来明确.

abstractsObjective To determine the clinical effect of Friend-Ⅰ External Physical Vibration Lithecbole (EPVL) by Meta-analysis.Methods Pubmed,Embase,Medline,Cochrane Library,Chinese National Knowledge Infrastructure were searched for clinical trials comparing EPVL with the conventional treatment.The quality of included studies was assessed and Meta-analysis was conducted by Review Manager 5.3 software.Results Five randomized or Quasi-randomized controlled trials met the inclusion criteria.The first day stone expulsion rate of EPVL group was superior to the control group (OR =4.95,95％ CI:3.35-7.32,P ＜0.000 01).Both one-week (OR =3.13,95％ CI:1.95-5.04,P ＜0.000 01) and two-week stone free rate (OR =4.50,95％ CI:2.02-10.00,P =0.000 2) were statistically higher in the EPVL group than that in the control group.No severe adverse event occurred during the follow-up.Conclusions Our study suggested that EPVL could be the effective treatment for upper urinary tract residual stone.However,more high quality randomized controlled trials are needed to better affirm this.