摘要目的 通过分析早产儿脑病(EOP) 颅脑磁共振影像学表现,为EOP早期诊断、早期防治提供依据.方法 收集 2009年1月1日至2014年12月31日复旦大学附属儿科医院新生儿科早产儿的颅脑磁共振成像(MRI)及临床资料,总结分析EOP的颅脑MRI表现形式和特点.结果 共有2 718例早产儿完成颅脑MRI检查纳入研究,其中颅脑MRI显示正常1 599例(58.8%),EOP 678例(24.9%).EOP以非囊性病例为主(78.8%,共534例),囊性EOP占21.2%(144例).EOP病变大多分布于侧脑室周围和脑叶白质,其中囊性病灶主要分布于侧脑室体部旁白质(71例,49.3%),其他部位仅少量分布,16.7%囊性病灶分布于额叶白质,10.4%囊性病灶分布于侧脑室前角旁白质.非囊性病例病灶分布主要在顶叶白质(134例,25.1%),其次为侧脑室体部旁白质(111例,20.8%)、额叶白质(108例,20.2%)、基底节(101例,18.9%).结论 完成颅脑MR检查早产儿中,EOP发生率为24.9%,其中囊性EOP占21.2%,非囊性EOP占78.8%,囊性病灶主要分布于侧脑室体部旁白质,非囊性病灶多分布于顶叶白质、侧脑室体部旁白质、额叶白质以及基底节.

abstractsObjective To explore the MRI manifestation of encephalopathy of prematurity (EOP),so as to find an access to the early prevention,early diagnosis,effective treatment and prognosis.Methods A total of 2 718 premature infants were collected,MRI and clinical data were analyzed who were admitted to NICU of Children′s Hospital of Fudan University between January 1,2009 and December 31,2014.The manifestation and lesions distribution in MRI were analyzed.Results All the 2 718 preterm infants underwent MRI.58.8% (1 599/2 718) of which had normal MRI apperance,whereas 24.9% (678/2 718) showed manifestations of EOP.78.8% (534/678) EOP were non-cystic EOP.21.2% (144/678) EOP were cystic EOP.Periventricular and cerebral lobe white matter were primary distributions of these lesions.Cystic lesions were primarily distributed in the body of periventricular whiter matter (49.3%).However,more non-cystic EOP were found in cerebral parietal lobe whiter matter (25.1%).Non-cystic EOP were also distributed in the body of periventricular whiter matter,frontal lobe and basal ganglia(20.8%,20.2% and 18.9%,respectively).Conclusions The morbidity rate of EOP in preterm infants was 24.9%.21.2% (144/678) EOP were cystic EOP.78.8% (534/678) EOP were non-cystic EOP.Cystic lesions were primarily distributed in the body of periventricular whiter matter.Non-cystic EOP were also distributed in the body of periventricular whiter matter,frontal lobe and basal ganglia.