摘要目的 观察钾通道开放剂(QO-58)对大鼠碘乙酸钠所致骨关节炎疼痛的影响.方法 大鼠右侧膝关节腔内单次注入3 mg/50 μl碘乙酸钠建立骨关节炎疼痛模型,模型成功后腹腔注射给予化合物50 mg/kg QO-58,观察其单次给药以及多次给药对大鼠骨关节炎疼痛模型机械刺痛和辐射热痛痛阈的影响.结果 单次腹腔注射给予化合物QO-58,于6 h和10 h显著提高大鼠骨关节炎疼痛模型机械刺痛和辐射热痛痛阈.从第10~14天每天1次腹腔注射给予化合物QO-58,显著提高第12、14天大鼠骨关节炎疼痛模型机械刺痛和辐射热痛痛阈.结论 化合物QO-58能够有效缓解碘乙酸钠所致大鼠骨关节炎疼痛.

abstractsObjective To determine the effects of QO-58 on pain behavior associated with monosodium iodoacetate (MIA)-induced OA.Methods The OA model was established with an intra-articular injection of 3 mg/50 MIA through the right patellar ligament.Then the model rats were treated with 50 mg/kg QO-58 by intraperitoneal injection,and pain-related behaviors were assessed by single administration and multiple administrations of QO-58.Results Single adminstration of QO-58 increased the mechanical threshold and prolonged the withdrawal latency of OA pain with the antinociceptive effect occurring at 6 h and 10 h.Compound QO-58 was administered intraperitoneally once a day from day 10 to 14.QO-58 significantly increased the mechanical threshold and prolonged the withdrawal latency of OA rats at 12 and 14 days.Conclusion QO-58 showed antinociceptive effects for OA pain in the MIA model after pain development.QO-58 may be an alternative therapeutic treatment for OA.