摘要目的:评估不同麻醉方案对无痛胃镜检查患者术后复苏速度和恢复质量的影响。方法:随机对照试验。前瞻性纳入2023年4至12月海南医学院附属海南省肿瘤医院行无痛胃镜检查的美国麻醉医师协会分级（ASA）Ⅰ~Ⅱ级患者150例，根据不同麻醉方法，采用随机数字表法分为3组：丙泊酚组（P组）、瑞马唑仑组（R组）和瑞马唑仑+氟马西尼组（RF组），每组50例。比较3组患者术后苏醒时间以及复苏室停留时间。并于患者苏醒后10、20 min分别进行认知功能（定向力评分）、行走能力以及精细运动能力（包括反应速度、急速点击和视觉记忆）评估，同时记录3组患者低血压、头晕、恶心呕吐等不良反应发生情况。结果:P组患者男29例，女21例，年龄（34±6）岁；R组男27例，女23例，年龄（36±8）岁；RF组男26例，女24例，年龄（33±7）岁；所有患者均顺利完成胃镜检查。RF组患者苏醒时间和复苏室停留时间分别为（47±15）s、（26±5）min，均短于R组［（489±92）s、（35±6）min］和P组［（196±61）s、（31±7）min］（均 P<0.05）。RF组患者苏醒后10 min定向力评分为（79.0±10.5）分，优于R组患者（70.0±11.7）分（ P<0.05）。RF组患者苏醒后10、20 min行走能力测试成绩［（23.6±10.8）、（48.0±4.5）分］优于R组［（15.4±11.1）、（47.6±4.8）分］（均 P<0.05），反应速度测试成绩［（851.0±150.9）、（547.0±114.0）ms］和急速点击测试成绩［（758.0±73.2）、（629.0±128.9）ms］优于R组［（1 151.0±206.0）、（732.0±135.1）ms］、［（893.0±110.9）、（765.8±125.8）ms］和P组［（985.0±225.3）、（613.0±123.2）ms］、［（831.0±87.7）、（691.0±115.8）ms］（均 P<0.05）。P组低血压发生率为18%（9/50），高于R组［4%（2/50）］和RF组［2%（1/50）］（均 P<0.05）。头晕及恶心呕吐发生率差异均无统计学意义（均 P>0.05）。 结论:氟马西尼可以缩短应用瑞马唑仑镇静患者的苏醒时间及复苏室停留时间，并加快其认知功能、行走能力及精细运动能力的恢复。

abstractsObjective:To estimate the impacts of different anesthetic protocols on the speed and quality of postoperative resuscitation in patients undergoing painless gastroscopy.Methods:This was a prospectively designed randomized control study that included 150 patients who underwent painless gastroscopy in Hainan Cancer Hospital affiliated to Hainan Medical College between April and December of 2023. All the patients, classified as American Society of Aneshesiologists (ASA) Grade Ⅰ or Ⅱ, were randomly divided into three groups with different anesthetic protocols, including propofol group (group P), remimazolam group (group R) and remimazolam with flumazenil group (group RF). There were eventually 50 patients in each group. The three groups of patients were compared for their resuscitation time and the time that they stayed in the resuscitation room (addressed as"room time"below). At 10 min and 20 min after resuscitation, each patient was tested for recognition ability (orientation score), walking ability and fine motor skill (including reaction speed, quick-click ability and visual memory), respectively, with possible adverse reactions recorded spontaneously, such as hypotension, dizziness, nausea and vomitus.Results:There were 29 males and 21 females in group P with an average age of (34±6) years, 27 males and 23 females in group R with an average age of (36±8) years, and 26 males and 24 females in group RF with an average age of (33±7) years, respectively. All examinations for each patient were successfully completed with no interruptions. The resuscitation time and room time of group RF were (47±15) s and (26±5) min,respectively, which were both shorter than those in either group R [(489±92) s and (35±6) min] or group P [(196±61) s and (31±7) min] (all P<0.05). The orientation score of patients in group RF at 10 min after resuscitation was (79.0±10.5), which was significantly higher than that in group R (70.0±11.7) ( P<0.05). The patients′ walking ability score of group RF at 10 min and 20 min after resuscitation were [(23.6±10.8), (48.0±4.5)], which were better than those in group R[(15.4±11.1), (47.6±4.8)] (both P<0.05). The patients′ reaction speed and quick-click scores of group RF were [(851.0±150.9), (547.0±114.0) ms] and [(758.0±73.2), (629.0±128.9) ms], which were better than those in either group R [(1 151.0±206.0), (732.0±135.1) ms], [(893.0±110.9), (765.8±125.8) ms] or group P [(985.0±225.3), (613.0±123.2) ms], [(831.0±87.7), (691.0±115.8) ms] (all P<0.05). The incidence rate of hypotension in group P was 18% (9/50), higher than that in either Group R [4% (2/50)] or group RF [2% (1/50)] (all P<0.05). The incidence rates of dizziness, nausea and vomitus were comparable among all the three groups with no statistical differences (all P>0.05). Conclusion:In patients undergoing anesthesia with remazolam, the use of flumazenil can not only shorten the resuscitation time and the time that the patients need to stay in the resuscitation room, but also speed up the recovery of the patients′ recognition, walking and fine motor skill abilities.