摘要为探讨罗伯逊易位（又称罗氏易位）携带者行染色体结构重排的植入前遗传学检测（PGT-SR）获得胚胎的染色体状态和辅助生殖临床结局，回顾性分析2017年2月至2023年12月解放军总医院第一医学中心112例染色体罗氏易位携带者（男51例，女61例）进行的148个PGT-SR治疗周期临床资料。rob（13；14）是最常见的易位形式，占65.2%（73/112）。720枚囊胚中可移植胚胎为303枚（42.1%）。胚胎的易位染色体亲本来源分析结果显示，男方携带者可移植胚胎比例高于女方携带者［50.0%（149/298）比36.5%（154/422）， P<0.001］；临床妊娠率高于女方携带者，但差异无统计学意义［62.9%（39/62）比49.4%（38/77）， P=0.154］。共139个囊胚移植周期，临床妊娠率55.4%（77/139），流产率14.3%（11/77）。罗氏易位携带者在PGT-SR治疗周期中，男性携带者比女性携带者获得更多的可移植胚胎。

abstractsA total of 112 carriers (51 males and 61 females) with Robertsonian translocations who underwent 148 cycles of preimplantation genetic testing for structural rearrangements (PGT-SR) between February 2017 and December 2023 at the First Center of General Hospital of Chinese PLA were recruited. The heterologous type rob (13; 14) was the most common form of translocation, which accounted for 65.2% (73/112). The total euploidy rate of blastocysts was 42.1% (303/720). Male carriers had higher rate of euploid embryo than female carriers [50.0% (149/298) vs 36.5% (154/422), P<0.001]. Likewise, the clinical pregnancy rate in male carriers was higher than female carriers, but the difference was not statistically significant [62.9% (39/62) vs 49.4% (38/77), P=0.154]. There were 139 transferrable embryos, with a clinical pregnancy rate of 55.4% (77/139) and abortion rate of 14.3% (11/77). The current study indicates that male carriers with Robertsonian translocations had higher rate of euploid embryo than female carriers in PGT-SR cycles.