摘要炎症性肠病（IBD）是一种慢性非特异性肠道炎症性疾病，发病机制不明。部分IBD患者对常规药物治疗反应不佳。目前认为哺乳动物雷帕霉素靶蛋白（mTOR）可通过PI3K/AKT/mTOR、TLR4/MAPK/mTOR和AMPK/mTOR等多种机制影响肠道自噬和炎症过程，从而影响疾病的发生发展过程。通过靶向mTOR信号通路可为IBD的治疗提供新的可能。本文就mTOR信号通路在IBD中的作用机制以及靶向mTOR信号通路治疗IBD进行总结。

abstractsInflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease with unknown pathogenesis, and some IBD patients do not respond well to conventional medications. Currently, mammalian target of rapamycin (mTOR) can affect intestinal autophagy and inflammation progress through various mechanisms such as PI3K/AKT/mTOR, TLR4/MAPK/mTOR and AMPK/mTOR. By this way, mTOR can play a significant role in its pathogenesis. Targeting mTOR signaling pathway provides new therapeutic options for IBD. In this article, the mechanisms of mTOR signaling pathway in IBD and the targeted treatment of mTOR signaling pathway for IBD were summarized.