摘要炎症性肠病（IBD）的发病机制非常复杂，包括遗传易感性、环境因素、肠道菌群紊乱、上皮屏障功能障碍和免疫系统失调等多个因素。其中，肠道微生物起着重要作用。值得关注的是，嗜黏蛋白阿克曼菌是一种与IBD有潜在关联的肠道细菌。本文总结嗜黏蛋白阿克曼菌在IBD的作用机制，包括增强肠道屏障、调节炎症反应、与肠道菌群的相互作用等方面，及其在IBD治疗中的潜力。此外，还探讨嗜黏蛋白阿克曼菌的菌株特异性、安全性等相关问题。

abstractsThe pathogenesis of inflammatory bowel disease (IBD) is complex, including multiple factors such as genetic predisposition, environmental factors, intestinal microbiota disorders, epithelial barrier dysfunction, and immune system dysregulation. Among these factors, the gut microbiome plays an important role. Notably, Akkermansia. muciniphila is an intestinal bacterium potentially associated with IBD. This review summarizes the mechanism of action of Akkermansia. muciniphila in IBD, including strengthening the intestinal barrier, modulating inflammatory responses, interacting with the gut microbiome, and its potential in IBD treatment. Additionally, the strain specificity and safety of Akkermansia.muciniphila are also discussed.