换一批miR-146a在自身免疫性疾病发病机制及临床诊疗研究中的进展
The potential role of miR-146a in the pathogenesis and diagnosis of autoimmune diseases
摘要微小mRNA( miR)是一类长约22个核苷酸的非编码RNA,通过作用于相应mRNA在转录后水平调节基因表达,在炎性反应和自身免疫病中发挥重要作用.近期关于miR-146a在自身免疫性疾病中发挥作用的研究备受关注.在此对miR-146a与几种常见自身免疫性疾病发病机制的相关性及其潜在临床应用价值进行阐述.
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abstractsMicroRNA(miR),a type of 22nt non-coding RNA,modulate gene expression at posttranscriptional level by interacting with targeting mRNA and play an important role in both inflammatory reaction and autoimmune diseases.Especially,the expression of miR-146a in autoimmune diseases has gotten more and more attention in recent studies.This review summarized the correlation between the expression of miR-146a and the pathogenesis of some common autoimmune diseases.What's more,the potential role of miR-146a in the clinical diagnosis of autoimmune diseases are also discussed.
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关键词
自身免疫疾病微小RNAs关节炎,类风湿红斑狼疮,系统性Autoimmune diseasesMicroRNAsArthritis,rheumatoidLupus erythematosus,systemic
分类号
R4
栏目名称
DOI
10.3760/cma.j.issn.1009-9158.2012.03.003
发布时间
2012-06-28（万方平台首次上网日期，不代表论文的发表时间）
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