摘要尿液内排出白蛋白提示肾脏损伤,被认为是肾脏疾病和心脑血管疾病进展的危险因子,尿白蛋白检测的临床应用越来越广.尿白蛋白在不同常规检测系统间存在差异,尿白蛋白的参考物质和参考测量程序的建立尚未完成.本文介绍了尿白蛋白检测在临床应用中的进展、不同检测方法学的原理及差异,以及尿白蛋白参考物质和参考测量程序的最新进展.

abstractsUrinary excretion of albumin indicates kidney damage and is recognized as a risk factor for progression of kidney disease and cardiovascular disease,resulting a widespread clinical utilization of urine albumin measurement.Considerable inter-method difference has been reported for urine albumin,there are no available reference materials and no reference measurement procedures for urine albumin.This review discusses the clinical utilization of urine albumin in recent years,the principles of existing measurement systems and difference of results among systems,and the current status of work about reference materials and reference measurement procedures.