摘要不恰当的抗生素经验治疗以及延迟的抗生素针对性治疗与增高的临床死亡率高度相关.由于传统的微生物培养与鉴定技术依赖于病原微生物生长而耗时较长,临床常常采用经验性广谱抗生素治疗感染性疾病,这又进一步促进了耐药的发生.为了改变这一现状,临床微生物学实验室应尽可能提供早期快速病原学报告,以实现从针对性的起始抗感染治疗或经验治疗到针对性治疗的及时转换.临床微生物学实验室应整合各种微生物学快速检验技术,优化工作流程,建设快速反应型临床微生物学实验室.

abstractsInadequate empirical antibiotic therapy and delayed target therapy have been demonstrated to be significantly associated with higher mortality.Because microbiological results based on the traditional culture and identification require quite a long time,empirical broad-spectrum antimicrobial therapy is often initiated according to the clinical presentation,which may resulting in the development of antimicrobial resistance.One of the strategies to alter the dilemma situation is that the initial empirical therapy is adjusted to definitive therapy as early as possible,which can only be done on the basis of rapid microbiological reports.Clinical microbiology laboratories should integrate a variety of rapid detection methods,improve working process,present reports as soon as possible,and bear fast-responsibility.