摘要血红蛋白病是由于正常血红蛋白比例失衡或异常血红蛋白出现所引起的一种遗传性血液病.血红蛋白分析对该病的筛查和诊断有着重要意义.从20世纪初开始,新的血红蛋白分析技术日益广泛应用于临床,包括琼脂糖凝胶电泳、高效液相色谱法和毛细管电泳法,质谱法也逐渐开始被应用.这些方法都有各自的特点,合理的联合使用能够使得血红蛋白分析更加科学可靠.

abstractsHemoglobinopathy is a kind of hereditary hematonosis caused by the disproportion among normal hemoglobins or formation of abnormal hemoglobins.Hemoglobin analysis plays an important role in screening and diagnosing hemoglobinopathy.Emerging methods have been applied continuously to hemoglobinometry since the early 20th century.Nowadays,agarose gel electrophoresis,high performance liquid chromatography and capillary electrophoresis are widely used with mass spectrometry as the latest applied method.All these methods have their own features.Appropriate combination of these methods will lead to more scientific and reliable results.