摘要严重感染致死率高,其早期诊断至关重要.感染性疾病的传统诊断指标,包括降钙素原、白细胞计数、CRP等,虽然这些指标有一定的敏感性和特异性,但仍不能实现感染的早期诊断.近来,中性粒细胞CD64因为其在细菌感染早期诊断方面较高的敏感性和特异性而受到广泛关注.中性粒细胞CD64表达的流式细胞检测可用于细菌感染所引起的感染性疾病的早期诊断,如呼吸道感染、败血症、新生儿重症感染、烧伤和术后感染等.若将中性粒细胞CD64联合其他反应炎症的指标联合检测,则可以进一步提高感染性疾病诊断的敏感性和特异性.流式细胞术检测中性粒细胞CD64将在感染性疾病诊断、病情监测、预后判断、疗效评估等多个方面发挥重要作用.

abstractsThe early diagnosis of serious infection is very important since the fatality rate is quite high.Traditional diagnostic methods of infection includes procalcitonin,leukocyte count,CRP and so on,of which the sensitivity and specificity is not able to achieve the early diagnosis.Recently,neutrophil CD64 has been widely concerned for the high sensitivity and specificity in early diagnosis of bacterial infection.Flow cytometry is applied to detect neutrophil CD64 in early diagnosis of infectious diseases including respiratory infection,septicemia,neonatal intensive infection,burn and postoperative infection.What's more,the sensitivity and specificity can be further improved if neutrophil CD64 was combined with other inflammatory markers.Thus,neutrophil CD64 detected by flowy cytometry plays an important role in the diagnosis,monitoring,prognosis,therapeutic effect evaluation of infectious diseases.