摘要儿童检验指标参考区间对儿科临床的疾病诊断、疗效观察、预后判断及健康评估都起着至关重要的作用.但相对于成人,建立儿童参考区间面临更多的困难及挑战.本文结合儿童群体与儿科临床专业的特点,阐述了采用直接抽样和间接抽样方法建立儿童参考区间的流程与关键技术以及参考区间的转化与验证方法,以期为实验室制定儿科参考区间提供科学的方法学思路.

abstractsThe pediatric reference intervals in clinical laboratory play an important role in diagnosis of illness,therapeutic monitoring,prediction of prognosis and health evaluation.Compared with establishing reference interval for adults,there are more challenges to establish pediatric reference intervals.Therefore,the procedure and key technologies of direct method and indirect method are stated based on the characteristics of children population and pediatric,by which to define,transfer and validate pediatric reference intervals.This study will provide systematically methodological ideas for clinical laboratories to establish pediatric reference intervals.