FGF23-Klotho与骨代谢异常的相关性

FGF23-Klotho and its correlation with abnormal bone metabolism

二维码有效期 120s

摘要骨代谢异常是指由多种因素引起的骨组织中钙、磷等矿物质、成骨细胞和/或破骨细胞功能异常.FGF23-Klotho轴在骨-肾-甲状旁腺轴中起重要作用,参与调控骨矿物质代谢;同时FGF23-Klotho轴还影响维生素D和甲状旁腺素的合成和分泌.随着研究的深入,FGF23-Klotho轴有望成为骨代谢紊乱诊断和治疗的新靶点.

abstractsSkeletal metabolic disorder refers to multi-factors caused by bone tissue calcium, phosphorus and other minerals,osteoblasts and(or)osteoclast dysfunction.The FGF23-Klotho axis plays an important role in the bone-kidney-parathyroid axis and is involved in the regulation of bone mineral metabolism.At the same time, FGF23-Klotho axis affects the synthesis and secretion of vitamin D and parathyroid hormone.With the deepening of research,the FGF23-Klotho axis is promising to be the target of diagnosis and treatment of bone metabolic disorders.

作者刘越 ^[1] 张艳梅 ^[1] 赵虎 ^[1] 学术成果认领

作者单位复旦大学附属华东医院检验科,上海,200040 ^[1]

关键词骨疾病,代谢性 FGF23-Klotho轴骨代谢紊乱诊治靶点 Bone diseases metabolic FGF23-Klotho axis Skeletal metabolic disorders Target of diagnosis and treatment

主题词代谢(Metabolism)性(Sex)骨疾病(Bone Diseases)矿物质(Minerals)骨和骨组织(Bone and Bones)

栏目名称 专家论坛

DOI 10.3760/cma.j.issn.1009-9158.2017.11.002

发布时间 2017-12-06

基金项目

上海市科委引导项目 上海申康医院发展中心项目(SHDC22014003) Shanghai Science and Technology Committee“Lead Project” Shanghai Shenkang Hospital Development Center Project