摘要目的 探讨福州地区就诊人群B19病毒感染现状,为研究B19病毒感染与临床疾病的相关性提供依据.方法 回顾性分析2011至2016年于福建医科大学附属协和医院就诊的22089例患者血清B19V IgM和IgG的检测结果,按照不同性别、不同年龄段、正常和异常妊娠结局、健康人与血细胞减少患者等条件进行分组,并运用t检验和卡方检验等统计学方法进行分析.结果 2011至2016年间,就诊人群中细小病毒B19特异性IgM抗体阳性率为4.5%(998/22089),IgG阳性率为36.9%(8155/22089);女性患者的B19 IgM阳性率(4.8%,546/11374)高于男性患者(4.2%,452/10715)(χ2=4.333,P<0.05);中年、老年患者 IgG 阳性率(53.6%,3629/6772;54.3%,1542/2838)高于幼儿、少年、青年患者(36.0%,989/2747;25.4%,237/934;20.0%,1758/8797)P值均小于0.05,差异具有统计学意义;不良妊娠结局妇女IgM阳性率(8.2%,20/245)高于正常妊娠妇女(3.3%,23/688)(χ2=9.548,P<0.05).全血细胞减少患者、血小板减少患者、贫血患者IgG阳性率分别为39.8%(165/415)、38.1%(297/780)、35.4%(81/226),均高于健康体检人群 IgG 阳性率14.4%(78/543)(χ2分别为80.127,88.626,43.461;P值均小于0.05).结论 福州地区就诊人群中B19V感染率较高,是一种常见病毒传染性疾病,其感染可导致不良妊娠结局的发生,与全血细胞减少、血小板减少、贫血等造血系统疾病相关.

abstractsObjective To investigate the outpatient visitor′s B19 infection in Fuzhou area, study the correlation between B19 virus infection and clinical diseases.Methods The infection status of B19V IgM and IgG in 22 089 outpatient visitors in Fuzhou area from 2011 to 2016 has been retrospectively analyzed.The patients were divided into different groups according to sex,age,different pregnant outcomes, healthy people and hematopoietic system diseases.Results The positive rate in 22 089 patients of B19V IgM was 4.5%(998/22 089)and the IgG positive rate was 36.9%(8 155/22 089); The positive rate of B19V IgM in female patients(4.8%,546/11 374)was higher than male patients(4.2%,452/10 715)(χ2=4.333,P<0.05); The middle-aged and elderly patients IgG positive rate(53.6%,3 629/6 772;54.3%,1 542/2 838)were significantly higher than infants,children and young people(36.0%,989/2 747;25.4%,237/934;20.0%,1 758/8 797); The positive rate of IgM in adverse pregnancy outcomes (8.2%,20/245)was higher than normal pregnant women(3.3%,23/688)(χ2=9.548,P<0.05).In pancytopenia,thrombocytopenia and anemia patients, the positive rates of B19V IgG were 39.8%(165/415),38.1%(297/780)and 35.4%(81/226)respectively, all of which were higher than that in the healthy people(14.4%,78/543)(χ2=80.127,88.626,43.461; P<0.05).Conclusions The outpatient visitor′s infection rate of B19V in Fuzhou is high.B19V is a common virus who can lead to adverse pregnancy outcomes.What′s more, it also can lead to pancytopenia, thrombocytopenia, anemia or other related hematopoietic diseases.