摘要生长分化因子15（GDF-15）是转化生长因子-β（TGF-β）超家族的一个远支。其在心血管疾病的发生发展过程中具有一定的生理作用和临床意义，不仅可作为心血管疾病发生及进展的生物标志物，而且对于疾病的风险分层及远期预后亦具有一定意义。通过回顾GDF-15在心血管疾病方面的临床研究及基础实验，阐述GDF-15在动脉粥样硬化、急性冠状动脉综合征等心血管疾病的最新研究进展，以期为临床在疾病诊治过程中对生物标志物的选择提供依据。

abstractsGrowth differentiation factor-15 (GDF-15) is a distant branch of the transforming growth factor-β (TGF-β) superfamily. Recent studies indicate that GDF-15 plays important physiological roles and has clinical implication in the initiation and development of various cardiovascular diseases. GDF-15 can both be used as a biomarker for the evaluation of cardiovascular disease occurrence and progression and a predictor for the risk stratification and long-term prognosis of cardiovascular diseases. The purpose of this review is to illustrate the latest research progress of GDF-15 in atherosclerosis and acute coronary syndrome obtained through the clinical research and basic experiments in cardiovascular diseases, to provide evidence for the selection of GDF-15 as useful biomarkers in the diagnosis and treatment of cardiovascular diseases.