摘要目的 构建“重大新药创制”科技重大专项实施效果评价指标体系,为科学、客观、公正评价“新药专项”实施效果提供思路.方法 本应用文献调研法和德尔菲法构建“新药专项”实施效果评价指标体系,应用层次分析法确定评估体系各指标的权重.研究过程中,通过计算专家积极系数、权威系数、指标合理程度,一致性检验等最终确保研究结果的科学性、合理性.结果 构建了有针对性、系统性的“新药专项”实施效果评估指标体系,经过专家咨询和层次分析计算结果表明,在评价“新药专项”实施效果时,“产品成果”所占的权重最大为39.03％;其次是技术成果、理论成果、“组织管理成果”.为“新药专项”评估提供一定的方向,即评估时应该更加重视产品成果和技术成果的评估.结论 本研究构建的“新药专项”实施效果评价指标体系充分吸收了专家意见,最终所得权重量表科学、合理,为重大专项组织管理者、项目执行者考核与执行“新药专项”提供了决策依据.

abstractsObjective Establish an objective and fair evaluation index system for the implementation effectiveness of the National Major New Drug Development Program of China.Methods Based on literature review and Delphi method,the framework of the evaluation index system was built and analytic hierarchy process was applied to determine the priority of each indicator of the system.The objectiveness and validness of the results were assured by determining expert activeness coefficient,authority coefficient,indicator rationality,and by applying consistency check.Results A targeted and systematic evaluation index system was constructed for the National Major New Drug Development Program,and through expert consultation and analytic hierarchy process,the factor of product result was considered of the highest weight of 39.03％,followed by technical result,theoretical result and organization and management result.The evaluation index system suggested that product result and technical result are two relatively more significant factors to be considered during evaluation.Conclu sion After consultation on expert opinions,the evaluation index system for the National Major New Drug Development Program was constructed with each factor been assigned with a scientific and rational weight,and this will provide a guideline for the decision making of program administrators and evaluation practice.