摘要目的:探索医学领域新型研发机构开展转化导向的科研项目自主立项创新模式。方法:以细胞生态海河实验室2022年度开展的市级自主立项为例，从项目布局、经费、评审专家、承担单位、首席专家和交叉融合等方面总结医学领域新型研发机构转化导向的自主立项经验。结果:通过转化全链条项目布局、转化导向评审、汇聚高层次平台和人才、鼓励交叉融合等举措，进行了转化导向的市级科研项目自主立项实践，并据此提出思考和建议。结论:实验室的转化导向自主立项经验，对于医学领域新型研发机构挖掘、培育有转化潜力的科研项目，促进科技成果转化，助力新型研发机构在医学科技创新和转化中发挥引领支撑作用具有一定的借鉴意义。

abstractsObjective:To explore the innovation mode of independent transformation-oriented science and technology research program approval by medical new research & development (R&D) institution.Methods:Through analyzing the program layout, funds, review experts, undertaking units, chief experts and interdisciplinarity to summarize the experiences of the independent transformation-oriented municipal program approval by Haihe laboratory of Cell Ecosystem in 2022.Results:As a new medical R&D institution, which vigorously constructed by Tianjin, Haihe laboratory of Cell Ecosystem has carried out the practice of the independent transformation-oriented municipal program through the measures of layout of full-chain transformation, conducting transformation-oriented review, gathering high-level research talents, and emphasizing interdisciplinarity.Conclusions:The experiences of Haihe laboratory of Cell Ecosystem make significance for medical new R&D institutions to explore and cultivate scientific research program with transformation potential and to promote the transformation of scientific and technological achievements, which are powerful factors for new R&D institutions to play a role of pilot and provide important support to scientific and technological innovation and transformation.