摘要目的 比较同一条件下采用常规法、简易法和单剂量法3种化妆品防晒指数(SPF)人体测试法在中国人群中的测试结果,并评价后两种方法的应用价值.方法 将广州地区健康志愿者45例,按入选顺序随机分成3组,分别用常规法、简易法和单剂量法测试3种待测防晒化妆品的SPF值.由两名有经验的观察者在同一条件下独立判读结果.结果 简易法组和单剂量法组均比常规法组降低了受试者接受的紫外线辐照剂量,以单剂量法更为明显.常规法和单剂量法检测出的3种防晒化妆品的SPF值一致,且与产品的SPF预期值十分接近;简易法检测成本低、简便,但不能测出产品的具体SPF值,只能给出产品SPF值的大致范围,且两名观察者得到的结果不一致,所得SPF值的范围与常规法组结果不完全一致.结论 单剂量法有可能取代常规法进行防晒化妆品标识SPF值的检测;简易法可用于市场监管.

abstractsObjective To investigate the three methods for sun protection factor determination in vivo in Chinese under the same condition, and to evaluate the feasibility and reliability of the three methods. Methods There were 45 healthy volunteers in Guangzhou area were involved in the study. All of them were randomly divided into three groups. Among them 15 volunteers were in the current method group, 5 volunteers in the simplified method group, and 25 volunteers were in the single-exposure method group. Two standard sunscreens of SPF 4 and SPF 15 and one sunscreen labeled as SPF 20 were tested by all the three methods in the study. Two experienced observers read results, respectively, under the same conditions. Results The volunteers in the current method group received the largest dose of UV light.The simple method was next to it and the single-exposure reduced 4-5 folds of UV dose received. The results of the two observers in the current method group and the single-exposure group were very close. But the test results of P3 were not completely coincident between the two observers in the simplified method group. SPFs value of the three sunscreens were 4. 12, 16.09, and 22.60 obtained by the observer 1 and 4. 18, 15.92, and 21.97 obtained by the observer 2, respectively. In the simplified method group, SPFs values of ＜4, ＞15, ＞20 and ＜4, ＜15, ＞20 were obtained by the two observers. In the single-exposure method group, SPFs values of the three sunscreens were 4.04, 15.34, 21.33 by the observer 1 and 3. 96, 15.82, 21.33 by the observer 2, respectively. Conclusion The single-exposure method is convenient and easily to operate and may replace the current method some day. The simple method is not valuable in determination of SPF labeled on the packages of sunscreens, but may be useful in supervision of the market sunscreen products.